Dagmar Simon1, Kristin Kernland Lang. 1. Department of Dermatology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland. dagmar.simon@insel.ch
Abstract
PURPOSE OF REVIEW: Recent published work on atopic dermatitis focusing on the pathogenesis and epidemiology, which have a direct effect on treatment, is presented. RECENT FINDINGS: Worldwide, the incidence of atopic dermatitis is still increasing, although a plateau seems to be reached in certain industrialized countries. In addition to the filaggrin missense mutations, other mechanisms responsible for impaired skin-barrier function have been identified. These findings have a direct impact on therapy as well as behavior strategies. The barrier defect and the resulting inflammation in the skin, in particular interleukin (IL)-17-mediated responses, play an important role in promoting allergic airway responses and food allergy. SUMMARY: These recent findings on epithelial barrier defects, as well as cells and cytokines important for atopic dermatitis development, provide new insights into its pathogenesis, help to characterize patient subgroups, and identify new therapeutic strategies.
PURPOSE OF REVIEW: Recent published work on atopic dermatitis focusing on the pathogenesis and epidemiology, which have a direct effect on treatment, is presented. RECENT FINDINGS: Worldwide, the incidence of atopic dermatitis is still increasing, although a plateau seems to be reached in certain industrialized countries. In addition to the filaggrin missense mutations, other mechanisms responsible for impaired skin-barrier function have been identified. These findings have a direct impact on therapy as well as behavior strategies. The barrier defect and the resulting inflammation in the skin, in particular interleukin (IL)-17-mediated responses, play an important role in promoting allergic airway responses and food allergy. SUMMARY: These recent findings on epithelial barrier defects, as well as cells and cytokines important for atopic dermatitis development, provide new insights into its pathogenesis, help to characterize patient subgroups, and identify new therapeutic strategies.
Authors: Abdullah A Alangari; Keith Morris; Bashir A Lwaleed; Laurie Lau; Ken Jones; Rose Cooper; Rowena Jenkins Journal: Immun Inflamm Dis Date: 2017-03-30
Authors: Dagmar Simon; Peter A Eng; Siegfried Borelli; Roland Kägi; Christian Zimmermann; Catherine Zahner; Jürgen Drewe; Lorenzo Hess; Giovanni Ferrari; Stephan Lautenschlager; Brunello Wüthrich; Peter Schmid-Grendelmeier Journal: Adv Ther Date: 2014-01-17 Impact factor: 3.845