CONTEXT: Barrett esophagus is a metaplastic, premalignant lesion associated with approximately 0.5% annual incidence of progression to esophageal adenocarcinoma. Diagnosis and screening of Barrett esophagus and Barrett-related dysplasia relies on histologic evaluation of endoscopic mucosal biopsies, a process that is burdened with interobserver variability. OBJECTIVES: To review the histologic features and classification of Barrett esophagus and Barrett-related dysplasia, to discuss the underlying difficulties in diagnosis and pitfalls, and to provide a brief review of new developments related to therapeutic modalities for patients diagnosed with dysplasia. DATA SOURCES: Sources include a review of relevant literature indexed in PubMed (US National Library of Medicine). CONCLUSIONS: In spite of interobserver variability, histologic assessment of dysplasia is currently the accepted method of surveillance, and subsequent patient management is dictated by this evaluation. Although not universal, endoscopic therapy is increasingly important in replacing esophagectomy for patients with high-grade dysplasia or early carcinoma.
CONTEXT: Barrett esophagus is a metaplastic, premalignant lesion associated with approximately 0.5% annual incidence of progression to esophageal adenocarcinoma. Diagnosis and screening of Barrett esophagus and Barrett-related dysplasia relies on histologic evaluation of endoscopic mucosal biopsies, a process that is burdened with interobserver variability. OBJECTIVES: To review the histologic features and classification of Barrett esophagus and Barrett-related dysplasia, to discuss the underlying difficulties in diagnosis and pitfalls, and to provide a brief review of new developments related to therapeutic modalities for patients diagnosed with dysplasia. DATA SOURCES: Sources include a review of relevant literature indexed in PubMed (US National Library of Medicine). CONCLUSIONS: In spite of interobserver variability, histologic assessment of dysplasia is currently the accepted method of surveillance, and subsequent patient management is dictated by this evaluation. Although not universal, endoscopic therapy is increasingly important in replacing esophagectomy for patients with high-grade dysplasia or early carcinoma.
Authors: N Li; S Pasricha; W J Bulsiewicz; R E Pruitt; S Komanduri; H C Wolfsen; G W Chmielewski; F S Corbett; K J Chang; N J Shaheen Journal: Dis Esophagus Date: 2015-06-30 Impact factor: 3.429
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Authors: W Asher Wolf; Sarina Pasricha; Cary Cotton; Nan Li; George Triadafilopoulos; V Raman Muthusamy; Gary W Chmielewski; F Scott Corbett; Daniel S Camara; Charles J Lightdale; Herbert Wolfsen; Kenneth J Chang; Bergein F Overholt; Ron E Pruitt; Atilla Ertan; Srinadh Komanduri; Anthony Infantolino; Richard I Rothstein; Nicholas J Shaheen Journal: Gastroenterology Date: 2015-08-29 Impact factor: 22.682
Authors: Zhaojun Nie; Shu-Chi Allison Yeh; Michelle LePalud; Fares Badr; Frances Tse; David Armstrong; Louis W C Liu; M Jamal Deen; Qiyin Fang Journal: Front Physiol Date: 2020-05-13 Impact factor: 4.566
Authors: Elena Lastraioli; Tiziano Lottini; Jessica Iorio; Giancarlo Freschi; Marilena Fazi; Claudia Duranti; Laura Carraresi; Luca Messerini; Antonio Taddei; Maria Novella Ringressi; Marianna Salemme; Vincenzo Villanacci; Carla Vindigni; Anna Tomezzoli; Roberta La Mendola; Maria Bencivenga; Bruno Compagnoni; Mariella Chiudinelli; Luca Saragoni; Ilaria Manzi; Giovanni De Manzoni; Paolo Bechi; Luca Boni; Annarosa Arcangeli Journal: Oncotarget Date: 2016-09-13