Literature DB >> 2196879

Insulin enhancer binding protein has helix-loop-helix structure.

Y Shibasaki1, H Sakura, F Takaku, M Kasuga.   

Abstract

Insulin gene expression is restricted to pancreatic B cells and the 5' flanking region is responsible for the tissue specificity. The GCCATCTG motif in this region of the rat insulin 1 gene functions as an enhancer for insulin transcription. A cDNA coding for a GCCATCTG motif-binding protein (IEBP1) was isolated from a rat pancreatic B cell tumor lambda gt11 library. The IEBP1 protein was found to be the rat counterpart of the immunoglobulin (Ig) enhancer binding protein E12/47 having a helix-loop-helix domain. This result indicates that the Ig gene and insulin gene employ the same (or a similar) binding protein as a part of their transcriptional apparatus.

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Year:  1990        PMID： 2196879     DOI： 10.1016/0006-291x(90)91276-x

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  9 in total

1.  Insulin gene expression in nonexpressing cells appears to be regulated by multiple distinct negative-acting control elements.

Authors:  S R Cordle; J Whelan; E Henderson; H Masuoka; P A Weil; R Stein
Journal:  Mol Cell Biol       Date:  1991-05       Impact factor: 4.272

2.  The insulin enhancer binding site 2 (IEB2; FAR) box of the insulin gene regulatory region binds at least three factors that can be distinguished by their DNA binding characteristics.

Authors:  M L Read; S B Smith; K Docherty
Journal:  Biochem J       Date:  1995-07-01       Impact factor: 3.857

3.  The helix-loop-helix transcription factor USF (upstream stimulating factor) binds to a regulatory sequence of the human insulin gene enhancer.

Authors:  M L Read; A R Clark; K Docherty
Journal:  Biochem J       Date:  1993-10-01       Impact factor: 3.857

Review 4.  Transcription of the insulin gene: towards defining the glucose-sensitive cis-element and trans-acting factors.

Authors:  D Melloul; E Cerasi
Journal:  Diabetologia       Date:  1994-09       Impact factor: 10.122

5.  Chronic exposure of HIT cells to high glucose concentrations paradoxically decreases insulin gene transcription and alters binding of insulin gene regulatory protein.

Authors:  L K Olson; J B Redmon; H C Towle; R P Robertson
Journal:  J Clin Invest       Date:  1993-07       Impact factor: 14.808

6.  Regulatory regions of rat insulin I gene necessary for expression in transgenic mice.

Authors:  F Dandoy-Dron; E Monthioux; J Jami; D Bucchini
Journal:  Nucleic Acids Res       Date:  1991-09-25       Impact factor: 16.971

7.  An insulinoma nuclear factor binding to GGGCCC motifs in human insulin gene.

Authors:  L Reibel; C Besnard; P Lores; J Jami; G Gacon
Journal:  Nucleic Acids Res       Date:  1993-04-11       Impact factor: 16.971

8.  Glucose modulates the binding activity of the beta-cell transcription factor IUF1 in a phosphorylation-dependent manner.

Authors:  W M MacFarlane; M L Read; M Gilligan; I Bujalska; K Docherty
Journal:  Biochem J       Date:  1994-10-15       Impact factor: 3.857

9.  Pancreatic beta-cell-type-specific transcription of the insulin gene is mediated by basic helix-loop-helix DNA-binding proteins.

Authors:  S R Cordle; E Henderson; H Masuoka; P A Weil; R Stein
Journal:  Mol Cell Biol       Date:  1991-03       Impact factor: 4.272
  9 in total

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