Literature DB >> 21968354

Candida albicans infections in renal transplant recipients: effect of caspofungin on polymorphonuclear cells.

Valeria Allizond1, Giuliana Banche, Franca Giacchino, Chiara Merlino, Daniela Scalas, Vivian Tullio, Giuseppe Garneri, Narcisa Mandras, Janira Roana, Anna Maria Cuffini.   

Abstract

This study aimed to compare the caspofungin immunomodulating activities against Candida albicans on polymorphonuclear cells (PMNs) from renal transplant recipients (RTRs) and healthy subjects (HSs). RTR PMNs showed a significantly reduced fungicidal activity compared with that of HS PMNs. Addition of caspofungin to RTR PMNs significantly potentiated the yeast intracellular killing rate, achieving values similar to those observed for HS PMNs. These data show that caspofungin is suitable for invasive candidiasis treatment in patients with immune system-impaired components.

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Year:  2011        PMID： 21968354      PMCID： PMC3232813          DOI： 10.1128/AAC.00521-11

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  23 in total

1.  Combined action of fluconazole and PMNs from uremic patients in clearing intracellular Candida albicans.

Authors:  V Tullio; A M Cuffini; F Giacchino; N Mandras; J Roana; L Comune; C Merlino; N A Carlone
Journal:  J Chemother       Date:  2003-06       Impact factor: 1.714

2.  Infectious complications after kidney transplantation: a single-center experience.

Authors:  G Pourmand; S Salem; A Mehrsai; M Taherimahmoudi; R Ebrahimi; M R Pourmand
Journal:  Transpl Infect Dis       Date:  2007-05-19       Impact factor: 2.228

3.  Enhanced enzymatic activity of Candida species responsible for oral candidiasis in renal transplant recipients.

Authors:  Mohamed M Anees; Adam Reich; Larysa Hirschberg; Ewa Watorek; Una M El-Shinnawi; Tarek Mostafa Ibrahiem; Solafa El-Shaarawy; Jacek C Szepietowski
Journal:  Mycoses       Date:  2010-05-09       Impact factor: 4.377

4.  Outcome of renal transplantation in eight patients with Candida sp. contamination of preservation fluid.

Authors:  M Matignon; F Botterel; V Audard; B Dunogue; K Dahan; P Lang; S Bretagne; P Grimbert
Journal:  Am J Transplant       Date:  2008-03       Impact factor: 8.086

Review 5.  Invasive fungal infections: the challenge continues.

Authors:  Antonino Gullo
Journal:  Drugs       Date:  2009       Impact factor: 9.546

6.  Caspofungin-mediated beta-glucan unmasking and enhancement of human polymorphonuclear neutrophil activity against Aspergillus and non-Aspergillus hyphae.

Authors:  Gregory A Lamaris; Russell E Lewis; Georgios Chamilos; Gregory S May; Amar Safdar; Thomas J Walsh; Issam I Raad; Dimitrios P Kontoyiannis
Journal:  J Infect Dis       Date:  2008-07-15       Impact factor: 5.226

7.  Effects of caspofungin (MK-0991) and anidulafungin (LY303366) on phagocytosis, oxidative burst and killing of Candida albicans by human phagocytes.

Authors:  U Frank; M Greiner; I Engels; F D Daschner
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2004-08-06       Impact factor: 3.267

Review 8.  Patients at high risk of invasive fungal infections: when and how to treat.

Authors:  Maria J G T Rüping; Jörg J Vehreschild; Oliver A Cornely
Journal:  Drugs       Date:  2008       Impact factor: 9.546

9.  Antifungal treatment strategies in high risk patients.

Authors:  Maria J G T Rüping; Jörg J Vehreschild; Oliver A Cornely
Journal:  Mycoses       Date:  2008-09       Impact factor: 4.377

10.  Oral Candida infection and colonization in solid organ transplant recipients.

Authors:  A Dongari-Bagtzoglou; P Dwivedi; E Ioannidou; M Shaqman; D Hull; J Burleson
Journal:  Oral Microbiol Immunol       Date:  2009-06
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