Literature DB >> 21967369

Rational polytherapy in the treatment of acute seizures and status epilepticus.

Claude G Wasterlain1, Roger Baldwin, David E Naylor, Kerry W Thompson, Lucie Suchomelova, Jerome Niquet.   

Abstract

We used a model of severe cholinergic status epilepticus (SE) to study polytherapy aimed at reversing the effects of seizure-induced loss of synaptic GABA(A) receptors and seizure-induced gain of synaptic NMDA receptors. Combinations of a benzodiazepine with ketamine and valproate, or with ketamine and brivaracetam, were more effective and less toxic than benzodiazepine monotherapy in this model of SE. Wiley Periodicals, Inc.
© 2011 International League Against Epilepsy.

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Year:  2011        PMID： 21967369      PMCID： PMC4540642          DOI： 10.1111/j.1528-1167.2011.03243.x

Source DB:  PubMed          Journal:  Epilepsia        ISSN： 0013-9580            Impact factor:   5.864


  5 in total

1.  Trafficking of GABA(A) receptors, loss of inhibition, and a mechanism for pharmacoresistance in status epilepticus.

Authors:  David E Naylor; Hantao Liu; Claude G Wasterlain
Journal:  J Neurosci       Date:  2005-08-24       Impact factor: 6.167

2.  Subunit-specific trafficking of GABA(A) receptors during status epilepticus.

Authors:  Howard P Goodkin; Suchitra Joshi; Zakaria Mtchedlishvili; Jasmit Brar; Jaideep Kapur
Journal:  J Neurosci       Date:  2008-03-05       Impact factor: 6.167

3.  A comparison of four treatments for generalized convulsive status epilepticus. Veterans Affairs Status Epilepticus Cooperative Study Group.

Authors:  D M Treiman; P D Meyers; N Y Walton; J F Collins; C Colling; A J Rowan; A Handforth; E Faught; V P Calabrese; B M Uthman; R E Ramsay; M B Mamdani
Journal:  N Engl J Med       Date:  1998-09-17       Impact factor: 91.245

4.  Development of a rat pilocarpine model of seizure/status epilepticus that mimics chemical warfare nerve agent exposure.

Authors:  Lauren M Tetz; Peter E Rezk; Ruthie H Ratcliffe; Richard K Gordon; Keith E Steele; Madhusoodana P Nambiar
Journal:  Toxicol Ind Health       Date:  2006-07       Impact factor: 2.273

Review 5.  Status epilepticus: pathophysiology and management in adults.

Authors:  James W Y Chen; Claude G Wasterlain
Journal:  Lancet Neurol       Date:  2006-03       Impact factor: 44.182
  5 in total
  17 in total

1.  Combined diazepam and MK-801 therapy provides synergistic protection from tetramethylenedisulfotetramine-induced tonic-clonic seizures and lethality in mice.

Authors:  Michael P Shakarjian; Mahil S Ali; Jana Velíšková; Patric K Stanton; Diane E Heck; Libor Velíšek
Journal:  Neurotoxicology       Date:  2015-03-14       Impact factor: 4.294

2.  Fruitful Futility: What We Learned From a Failed Clinical Trial of Out-of-Hospital Status Epilepticus Trial.

Authors:  Jong Woo Lee
Journal:  Epilepsy Curr       Date:  2016 May-Jun       Impact factor: 7.500

3.  Trafficking of NMDA receptors during status epilepticus: therapeutic implications.

Authors:  Claude G Wasterlain; David E Naylor; Hantao Liu; Jerome Niquet; Roger Baldwin
Journal:  Epilepsia       Date:  2013-09       Impact factor: 5.864

4.  Mechanisms of status epilepticus: α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor hypothesis.

Authors:  Suchitra Joshi; Jaideep Kapur
Journal:  Epilepsia       Date:  2018-08-29       Impact factor: 5.864

Review 5.  Pathophysiology of convulsive status epilepticus.

Authors:  Iván Sánchez Fernández; Howard P Goodkin; Rod C Scott
Journal:  Seizure       Date:  2018-08-06       Impact factor: 3.184

6.  Generalized seizure activity in an adult rhesus macaque (Macaca mulatta) during ketamine anesthesia and urodynamic studies.

Authors:  Kari L Christe; Una J Lee; Marie-Josee Lemoy; Leif A Havton
Journal:  Comp Med       Date:  2013-10       Impact factor: 0.982

7.  Rapid surface accumulation of NMDA receptors increases glutamatergic excitation during status epilepticus.

Authors:  David E Naylor; Hantao Liu; Jerome Niquet; Claude G Wasterlain
Journal:  Neurobiol Dis       Date:  2013-01-08       Impact factor: 5.996

Review 8.  Newer Antiepileptic Drugs for Status Epilepticus in Adults: What's the Evidence?

Authors:  Isabelle Beuchat; Jan Novy; Andrea O Rossetti
Journal:  CNS Drugs       Date:  2018-03       Impact factor: 5.749

9.  Dexmedetomidine stops benzodiazepine-refractory nerve agent-induced status epilepticus.

Authors:  Hilary S McCarren; Julia A Arbutus; Cherish Ardinger; Emily N Dunn; Cecelia E Jackson; John H McDonough
Journal:  Epilepsy Res       Date:  2018-01-31       Impact factor: 3.045

10.  Validating a model of benzodiazepine refractory nerve agent-induced status epilepticus by evaluating the anticonvulsant and neuroprotective effects of scopolamine, memantine, and phenobarbital.

Authors:  Cecelia Jackson; Cherish Ardinger; Kristin M Winter; John H McDonough; Hilary S McCarren
Journal:  J Pharmacol Toxicol Methods       Date:  2019-02-19       Impact factor: 2.285
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