Literature DB >> 21967357

Canine status epilepticus: a translational platform for human therapeutic trials.

Ilo E Leppik1, Edward N Patterson, Lisa D Coles, Elise M Craft, James C Cloyd.   

Abstract

Current treatment of human status epilepticus (SE) relies on drugs developed for chronic treatment of epilepsy. Many potent compounds have been discovered in animal models of SE. But they may never be useful for chronic treatment of epilepsy and thus not available for human use. Naturally occurring canine SE may become a translational platform for evaluating these compounds for eventual use in human trials. A pilot study of levetiracetam in canine SE demonstrated a 56% response rate compared to 10% for placebo. Based on these results we have obtained an NIH R-21 to further evaluate canine SE as a translational platform for developing new approaches for treating human SE. Wiley Periodicals, Inc.
© 2011 International League Against Epilepsy.

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Year:  2011        PMID： 21967357      PMCID： PMC3201761          DOI： 10.1111/j.1528-1167.2011.03231.x

Source DB:  PubMed          Journal:  Epilepsia        ISSN： 0013-9580            Impact factor:   5.864


  12 in total

1.  Status epilepticus treatment guidelines.

Authors:  Reetta Kälviäinen
Journal:  Epilepsia       Date:  2007       Impact factor: 5.864

2.  On the relevance of prolonged convulsive status epilepticus in animals to the etiology and neurobiology of human temporal lobe epilepsy.

Authors:  Robert S Sloviter; Colin A Zappone; Argyle V Bumanglag; Braxton A Norwood; Hemant Kudrimoti
Journal:  Epilepsia       Date:  2007       Impact factor: 5.864

Review 3.  AED doses: from animals to humans.

Authors:  I E Leppik
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4.  Pharmacokinetics and safety of a phenytoin prodrug given i.v. or i.m. in patients.

Authors:  I E Leppik; B A Boucher; B J Wilder; V S Murthy; C Watridge; N M Graves; R J Rangel; C A Rask; P Turlapaty
Journal:  Neurology       Date:  1990-03       Impact factor: 9.910

5.  Clinical findings, treatment, and outcome of dogs with status epilepticus or cluster seizures: 156 cases (1990-1995).

Authors:  S W Bateman; J M Parent
Journal:  J Am Vet Med Assoc       Date:  1999-11-15       Impact factor: 1.936

6.  A comparison of four treatments for generalized convulsive status epilepticus. Veterans Affairs Status Epilepticus Cooperative Study Group.

Authors:  D M Treiman; P D Meyers; N Y Walton; J F Collins; C Colling; A J Rowan; A Handforth; E Faught; V P Calabrese; B M Uthman; R E Ramsay; M B Mamdani
Journal:  N Engl J Med       Date:  1998-09-17       Impact factor: 91.245

7.  Canine status epilepticus: a retrospective study of 50 cases.

Authors:  S R Platt; M Haag
Journal:  J Small Anim Pract       Date:  2002-04       Impact factor: 1.522

8.  Risk factors for development of status epilepticus in dogs with idiopathic epilepsy and effects of status epilepticus on outcome and survival time: 32 cases (1990-1996).

Authors:  M Saito; K R Muñana; N J Sharp; N J Olby
Journal:  J Am Vet Med Assoc       Date:  2001-09-01       Impact factor: 1.936

9.  Clinical presentations of naturally occurring canine seizures: similarities to human seizures.

Authors:  Barbara G. Licht; Mark H. Licht; Kathleen M. Harper; Shili Lin; John J. Curtin; Linda L. Hyson; Kristen Willard
Journal:  Epilepsy Behav       Date:  2002-10       Impact factor: 2.937

10.  Effect of novel AMPA antagonist, NS1209, on status epilepticus. An experimental study in rat.

Authors:  Asla Pitkänen; Claus Mathiesen; Lars Christian B Rønn; Arne Møller; Jari Nissinen
Journal:  Epilepsy Res       Date:  2007-02-06       Impact factor: 3.045
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  6 in total

Review 1.  The pharmacology of imepitoin: the first partial benzodiazepine receptor agonist developed for the treatment of epilepsy.

Authors:  Chris Rundfeldt; Wolfgang Löscher
Journal:  CNS Drugs       Date:  2014-01       Impact factor: 5.749

2.  Canine status epilepticus treated with fosphenytoin: A proof of principle study.

Authors:  Edward E Patterson; Ilo E Leppik; Lisa D Coles; Michael Podell; Charles H Vite; William Bush; James C Cloyd
Journal:  Epilepsia       Date:  2015-05-07       Impact factor: 5.864

Review 3.  Dogs as a Natural Animal Model of Epilepsy.

Authors:  Wolfgang Löscher
Journal:  Front Vet Sci       Date:  2022-06-22

Review 4.  Intravenous and Intramuscular Formulations of Antiseizure Drugs in the Treatment of Epilepsy.

Authors:  Sima I Patel; Angela K Birnbaum; James C Cloyd; Ilo E Leppik
Journal:  CNS Drugs       Date:  2015-12       Impact factor: 5.749

5.  Repetitive transcranial magnetic stimulation in drug-resistant idiopathic epilepsy of dogs: A noninvasive neurostimulation technique.

Authors:  Marios Charalambous; Luc Van Ham; Bart J G Broeckx; Tom Roggeman; Sofie Carrette; Kristi Vonck; Roelof R Kervel; Ine Cornelis; Sofie F M Bhatti
Journal:  J Vet Intern Med       Date:  2020-10-03       Impact factor: 3.333

6.  Crowdsourcing reproducible seizure forecasting in human and canine epilepsy.

Authors:  Benjamin H Brinkmann; Joost Wagenaar; Drew Abbot; Phillip Adkins; Simone C Bosshard; Min Chen; Quang M Tieng; Jialune He; F J Muñoz-Almaraz; Paloma Botella-Rocamora; Juan Pardo; Francisco Zamora-Martinez; Michael Hills; Wei Wu; Iryna Korshunova; Will Cukierski; Charles Vite; Edward E Patterson; Brian Litt; Gregory A Worrell
Journal:  Brain       Date:  2016-03-31       Impact factor: 15.255
  6 in total

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