Bruce C Casto1, Michael A Pereira. 1. College of Public Health, The Ohio State University, Columbus, OH 43210, U.S.A. casto.44@osu.edu
Abstract
BACKGROUND: Concurrent and sequential administration of combinations of budesonide, bexarotene, suberoylanilide hydroxamic acid (SAHA) and atorvastatin were evaluated in A/J mice for prevention of lung tumors initiated by 4-(methylnitrosoamino)-1-(3-pyridyl)-1-butanol, NNK). MATERIALS AND METHODS: Individual drugs and their combinations were administered for 26 weeks after NNK initiation. For sequential administration, budesonide was given for 21 weeks followed by a second drug. RESULTS: Alone, budesonide, bexarotene, and SAHA caused a significant decrease in total and large tumors at 21 and 26 weeks. Concurrent treatment with budesonide and bexarotene or SAHA caused a significantly greater decrease in total tumors and large tumors than either drug administered alone. Sequential administration of all combinations (except budesonide/atorvastatin) gave a significant reduction in total and large tumors. Budesonide followed by SAHA and SAHA with atorvastatin yielded a greater reduction in large tumors. CONCLUSION: Combinations of drugs demonstrated a greater efficacy in preventing mouse lung tumors than did the individual agents.
BACKGROUND: Concurrent and sequential administration of combinations of budesonide, bexarotene, suberoylanilide hydroxamic acid (SAHA) and atorvastatin were evaluated in A/J mice for prevention of lung tumors initiated by 4-(methylnitrosoamino)-1-(3-pyridyl)-1-butanol, NNK). MATERIALS AND METHODS: Individual drugs and their combinations were administered for 26 weeks after NNK initiation. For sequential administration, budesonide was given for 21 weeks followed by a second drug. RESULTS: Alone, budesonide, bexarotene, and SAHA caused a significant decrease in total and large tumors at 21 and 26 weeks. Concurrent treatment with budesonide and bexarotene or SAHA caused a significantly greater decrease in total tumors and large tumors than either drug administered alone. Sequential administration of all combinations (except budesonide/atorvastatin) gave a significant reduction in total and large tumors. Budesonide followed by SAHA and SAHA with atorvastatin yielded a greater reduction in large tumors. CONCLUSION: Combinations of drugs demonstrated a greater efficacy in preventing mouselung tumors than did the individual agents.
Authors: Kim Tran; Renee Risingsong; Darlene B Royce; Charlotte R Williams; Michael B Sporn; Patricia A Pioli; Lalji K Gediya; Vincent C Njar; Karen T Liby Journal: Carcinogenesis Date: 2012-10-06 Impact factor: 4.944
Authors: Alberto Izzotti; Roumen Balansky; Francesco D'Agostini; Mariagrazia Longobardi; Cristina Cartiglia; Sebastiano La Maestra; Rosanna T Micale; Anna Camoirano; Gancho Ganchev; Marietta Iltcheva; Vernon E Steele; Silvio De Flora Journal: Carcinogenesis Date: 2013-05-24 Impact factor: 4.944
Authors: Stefan Prekovic; Karianne Schuurman; Isabel Mayayo-Peralta; Anna G Manjón; Mark Buijs; Selçuk Yavuz; Max D Wellenstein; Alejandro Barrera; Kim Monkhorst; Anne Huber; Ben Morris; Cor Lieftink; Theofilos Chalkiadakis; Ferhat Alkan; Joana Silva; Balázs Győrffy; Liesbeth Hoekman; Bram van den Broek; Hans Teunissen; Donna O Debets; Tesa Severson; Jos Jonkers; Timothy Reddy; Karin E de Visser; William Faller; Roderick Beijersbergen; Maarten Altelaar; Elzo de Wit; Rene Medema; Wilbert Zwart Journal: Nat Commun Date: 2021-07-16 Impact factor: 14.919