Literature DB >> 21964699

Influence of common preanalytical variations on the metabolic profile of serum samples in biobanks.

Ophélie Fliniaux1, Gwenaelle Gaillard, Antoine Lion, Dominique Cailleu, François Mesnard, Fotini Betsou.   

Abstract

A blood pre-centrifugation delay of 24 h at room temperature influenced the proton NMR spectroscopic profiles of human serum. A blood pre-centrifugation delay of 24 h at 4°C did not influence the spectroscopic profile as compared with 4 h delays at either room temperature or 4°C. Five or ten serum freeze-thaw cycles also influenced the proton NMR spectroscopic profiles. Certain common in vitro preanalytical variations occurring in biobanks may impact the metabolic profile of human serum.

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Year:  2011        PMID： 21964699     DOI： 10.1007/s10858-011-9574-5

Source DB:  PubMed          Journal:  J Biomol NMR        ISSN： 0925-2738            Impact factor:   2.835


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