Literature DB >> 2196461

Mechanisms by which EGF receptor and TGF alpha contribute to malignant transformation.

E Di Marco1, J H Pierce, S A Aaronson, P P Di Fiore.   

Abstract

Alterations affecting the epidermal growth factor/transforming growth factor alpha-responsive mitogenic pathway are frequently detected in malignancies. In particular, the epidermal growth factor receptor has been found overexpressed in a number of human tumors. Production and secretion of transforming growth factor type alpha has also been shown in several tumor cells but not in their normal counterparts. In this review we describe the establishment of in vitro model systems to study the transforming potential of these molecules and summarize our current understanding of the mechanisms involved in transformation by genes encoding a growth factor and a growth factor receptor.

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Year:  1990        PMID： 2196461

Source DB:  PubMed          Journal:  Nat Immun Cell Growth Regul        ISSN： 0254-7600


  12 in total

1.  Correlation between epithelial cell proliferation and histological grading in gastric mucosa.

Authors:  D A Lynch; N P Mapstone; A M Clarke; P Jackson; P Moayyedi; M F Dixon; P Quirke; A T Axon
Journal:  J Clin Pathol       Date:  1999-05       Impact factor: 3.411

2.  Proliferating cell nuclear antigen in oesophageal diseases; correlation with transforming growth factor alpha expression.

Authors:  J Jankowski; R McMenemin; C Yu; D Hopwood; K G Wormsley
Journal:  Gut       Date:  1992-05       Impact factor: 23.059

3.  Chronic activation of wild-type epidermal growth factor receptor and loss of Cdkn2a cause mouse glioblastoma formation.

Authors:  Jaime Acquaviva; Hyun Jung Jun; Julie Lessard; Rolando Ruiz; Haihao Zhu; Melissa Donovan; Steve Woolfenden; Abraham Boskovitz; Ami Raval; Roderick T Bronson; Rolf Pfannl; Charles A Whittaker; David E Housman; Al Charest
Journal:  Cancer Res       Date:  2011-10-10       Impact factor: 12.701

Review 4.  The role of evolutionarily conserved signalling systems in Echinococcus multilocularis development and host-parasite interaction.

Authors:  Klaus Brehm
Journal:  Med Microbiol Immunol       Date:  2010-04-08       Impact factor: 3.402

5.  Human transforming growth factor alpha (TGF-alpha) is digested to a smaller (1-43), less biologically active, form in acidic gastric juice.

Authors:  T Marchbank; R Boulton; H Hansen; R J Playford
Journal:  Gut       Date:  2002-12       Impact factor: 23.059

6.  Cot, a novel kinase of histone H3, induces cellular transformation through up-regulation of c-fos transcriptional activity.

Authors:  Hong Seok Choi; Bong Seok Kang; Jung-Hyun Shim; Yong-Yeon Cho; Bu Young Choi; Ann M Bode; Zigang Dong
Journal:  FASEB J       Date:  2007-08-27       Impact factor: 5.191

7.  Aptameric inhibition of p210bcr-abl tyrosine kinase autophosphorylation by oligodeoxynucleotides of defined sequence and backbone structure.

Authors:  R Bergan; Y Connell; B Fahmy; E Kyle; L Neckers
Journal:  Nucleic Acids Res       Date:  1994-06-11       Impact factor: 16.971

8.  Epidermal growth factor enhances repair of rat intestinal mucosa damaged by oral administration of methotrexate.

Authors:  M Hirano; R Iwakiri; K Fujimoto; H Sakata; T Ohyama; T Sakai; T Joh; M Itoh
Journal:  J Gastroenterol       Date:  1995-04       Impact factor: 7.527

9.  Association of the transmembrane TGF-alpha precursor with a protein kinase complex.

Authors:  L Shum; S A Reeves; A C Kuo; E S Fromer; R Derynck
Journal:  J Cell Biol       Date:  1994-05       Impact factor: 10.539

10.  Immunotherapy of human tumour xenografts overexpressing the EGF receptor with rat antibodies that block growth factor-receptor interaction.

Authors:  H Modjtahedi; S Eccles; G Box; J Styles; C Dean
Journal:  Br J Cancer       Date:  1993-02       Impact factor: 7.640
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