OBJECTIVE: Procalcitonin (PCT) has been increasingly used as a biomarker of infection. The purpose of this study was to evaluate its diagnostic value after hematopoietic stem cell transplantation (HSCT), where non-infectious febrile complications such as graft-versus-host disease frequently develop. METHODS: We retrospectively analyzed 144 febrile episodes (infections: 82, and noninfections: 62) in adult patients with hematological disorders, including 57 and 87 episodes in HSCT and non-HSCT patients, respectively. RESULTS: Of 57 febrile episodes in HSCT patients, 46 (86%) and 25 (44%) revealed positivity for C-reactive protein (CRP) and PCT, respectively. Among 87 febrile episodes in non-HSCT patients, 81 (93%) and 22 (25%) events showed positive results of CRP and PCT. Both of these biomarkers were associated with infectious episodes in univariate analysis. Multivariate analysis showed that a high cut-off level (>9.5 mg/dL) of CRP was a better indicator for infections than PCT in HSCT patients, while PCT positivity was more diagnostic for infections than any cutoff CRP level in non-HSCT patients. CONCLUSION: It may be necessary to interpret the results of these biomarkers with different orders of priority in transplant versus nontransplant patients.
OBJECTIVE: Procalcitonin (PCT) has been increasingly used as a biomarker of infection. The purpose of this study was to evaluate its diagnostic value after hematopoietic stem cell transplantation (HSCT), where non-infectious febrile complications such as graft-versus-host disease frequently develop. METHODS: We retrospectively analyzed 144 febrile episodes (infections: 82, and noninfections: 62) in adult patients with hematological disorders, including 57 and 87 episodes in HSCT and non-HSCT patients, respectively. RESULTS: Of 57 febrile episodes in HSCT patients, 46 (86%) and 25 (44%) revealed positivity for C-reactive protein (CRP) and PCT, respectively. Among 87 febrile episodes in non-HSCT patients, 81 (93%) and 22 (25%) events showed positive results of CRP and PCT. Both of these biomarkers were associated with infectious episodes in univariate analysis. Multivariate analysis showed that a high cut-off level (>9.5 mg/dL) of CRP was a better indicator for infections than PCT in HSCT patients, while PCT positivity was more diagnostic for infections than any cutoff CRP level in non-HSCT patients. CONCLUSION: It may be necessary to interpret the results of these biomarkers with different orders of priority in transplant versus nontransplant patients.
Authors: K S R Massaro; R Macedo; B S de Castro; F Dulley; M S Oliveira; M A S Yasuda; A S Levin; S F Costa Journal: Infection Date: 2014-09-30 Impact factor: 3.553
Authors: M Sato; H Nakasone; K Terasako-Saito; K Sakamoto; R Yamazaki; Y Tanaka; Y Akahoshi; H Nakano; T Ugai; H Wada; R Yamasaki; Y Ishihara; K Kawamura; M Ashizawa; S-i Kimura; M Kikuchi; A Tanihara; J Kanda; S Kako; J Nishida; Y Kanda Journal: Bone Marrow Transplant Date: 2014-01-13 Impact factor: 5.483
Authors: J Mensa; C Dueñas Gutiérrez; C Cardozo; L Rodríguez Fernández; M Kestler; P Muñoz; E Bouza Journal: Rev Esp Quimioter Date: 2020-02-14 Impact factor: 1.553
Authors: C M Lucena; M Rovira; A Gabarrús; X Filella; C Martínez; R Domingo; A Torres; C Agustí Journal: Bone Marrow Transplant Date: 2016-10-31 Impact factor: 5.483
Authors: Alex van Belkum; Géraldine Durand; Michel Peyret; Sonia Chatellier; Gilles Zambardi; Jacques Schrenzel; Dee Shortridge; Anette Engelhardt; William Michael Dunne Journal: Ann Lab Med Date: 2012-12-17 Impact factor: 3.464