BACKGROUND: The Glial cell-line derived neurotrophic factor (GDNF) is part of the TGF-β superfamily and is abundantly expressed in the central nervous system. Changes in GDNF homeostasis have been reported in affective disorders. AIM: To assess serum GDNF concentration in elderly subjects with late-life depression, before antidepressant treatment, as compared to healthy elderly controls. METHODS: Thirty-four elderly subjects with major depression and 37 age and gender-matched healthy elderly controls were included in this study. Diagnosis of major depression was ascertained by the SCID interview for DSM-IV and the severity of depressive symptoms was assessed by the Hamilton Depression Rating Scale (HDRS-21). Serum GDNF concentration were determined by sandwich ELISA. RESULTS: Patients with major depression showed a significant reduction in GDNF levels as compared to healthy elderly controls (p < 0.001). Also, GDNF level was negatively correlated with HDRS-21 scores (r = -0.343, p = 0.003). DISCUSSION: Our data provide evidence that GDNF may be a state marker of depressive episode in older adults. Changes in the homeostatic control of GDNF production may be a target to development of new antidepressant strategies.
BACKGROUND: The Glial cell-line derived neurotrophic factor (GDNF) is part of the TGF-β superfamily and is abundantly expressed in the central nervous system. Changes in GDNF homeostasis have been reported in affective disorders. AIM: To assess serum GDNF concentration in elderly subjects with late-life depression, before antidepressant treatment, as compared to healthy elderly controls. METHODS: Thirty-four elderly subjects with major depression and 37 age and gender-matched healthy elderly controls were included in this study. Diagnosis of major depression was ascertained by the SCID interview for DSM-IV and the severity of depressive symptoms was assessed by the Hamilton Depression Rating Scale (HDRS-21). Serum GDNF concentration were determined by sandwich ELISA. RESULTS:Patients with major depression showed a significant reduction in GDNF levels as compared to healthy elderly controls (p < 0.001). Also, GDNF level was negatively correlated with HDRS-21 scores (r = -0.343, p = 0.003). DISCUSSION: Our data provide evidence that GDNF may be a state marker of depressive episode in older adults. Changes in the homeostatic control of GDNF production may be a target to development of new antidepressant strategies.
Authors: Kr Roversi; Caren Tatiane de David Antoniazzi; L H Milanesi; H Z Rosa; M Kronbauer; D R Rossato; T Duarte; M M Duarte; Marilise E Burger Journal: Mol Neurobiol Date: 2019-02-11 Impact factor: 5.590
Authors: Breno S Diniz; Antonio L Teixeira; Rodrigo Machado-Vieira; Leda L Talib; Marcia Radanovic; Wagner F Gattaz; Orestes V Forlenza Journal: J Gerontol B Psychol Sci Soc Sci Date: 2014-08-22 Impact factor: 4.077
Authors: Ajaykumar N Sharma; Bruno Fernando Borges da Costa e Silva; Jair C Soares; André F Carvalho; Joao Quevedo Journal: J Affect Disord Date: 2016-03-02 Impact factor: 4.839
Authors: André R Brunoni; Rodrigo Machado-Vieira; Carlos A Zarate; Erica L M Vieira; Leandro Valiengo; Isabela M Benseñor; Paulo A Lotufo; Wagner F Gattaz; Antonio L Teixeira Journal: Prog Neuropsychopharmacol Biol Psychiatry Date: 2014-08-27 Impact factor: 5.067
Authors: Taiane de Azevedo Cardoso; Thaise Campos Mondin; Carolina David Wiener; Melina Bazili Marques; Briane de Ávila Fucolo; Ricardo Tavares Pinheiro; Luciano Dias Mattos de Souza; Ricardo Azevedo da Silva; Karen Jansen; Jean Pierre Oses Journal: Neurochem Res Date: 2014-06-05 Impact factor: 3.996