BACKGROUND: The usefulness of single-balloon enteroscopy (SBE) has not been evaluated in children with known or suspected Crohn's disease (CD). OBJECTIVE: The objectives of this study are to evaluate the diagnostic yield of SBE for pediatric CD by comparing it with US and magnetic resonance enterography (MRE). DESIGN: Single-center prospective study. SETTING: Tertiary-care referral hospital. PATIENTS: Between February 2009 and April 2010, 20 pediatric patients (ages 8-18 years) with suspected inflammatory bowel disease (IBD) or with a previous diagnosis of CD with suspected persistent small-bowel disease were enrolled. INTERVENTIONS: All patients underwent proximal and distal SBE, 17 patients also underwent US combined with Doppler flow measurements, and 18 underwent MRE. MAIN OUTCOME MEASUREMENTS: The findings of US with Doppler flow measurements and MRE were compared with those with SBE. RESULTS: The mean patient age was 15.0 years (range 11.3-18 years, 70% male). Of 14 patients with suspected IBD, 8 had a diagnosis of CD made after SBE. Activity in the small bowel was found in 14 patients (70%) with both suspected and previously diagnosed CD. Twelve patients (60%) had small-bowel disease that was out of reach of conventional endoscopy. Three patients (15%) had small-bowel activity solely in the jejunum, which was not detected by either MRE or US. LIMITATIONS: Single-center study with small sample size. CONCLUSIONS: SBE can be used in children to accurately assess small-bowel disease and CD. Small-bowel activity may be identified by SBE in some patients in whom it may not be apparent despite use of conventional upper endoscopy, ileocolonoscopy, US with Doppler flow measurements, or MRE.
BACKGROUND: The usefulness of single-balloon enteroscopy (SBE) has not been evaluated in children with known or suspected Crohn's disease (CD). OBJECTIVE: The objectives of this study are to evaluate the diagnostic yield of SBE for pediatric CD by comparing it with US and magnetic resonance enterography (MRE). DESIGN: Single-center prospective study. SETTING: Tertiary-care referral hospital. PATIENTS: Between February 2009 and April 2010, 20 pediatric patients (ages 8-18 years) with suspected inflammatory bowel disease (IBD) or with a previous diagnosis of CD with suspected persistent small-bowel disease were enrolled. INTERVENTIONS: All patients underwent proximal and distal SBE, 17 patients also underwent US combined with Doppler flow measurements, and 18 underwent MRE. MAIN OUTCOME MEASUREMENTS: The findings of US with Doppler flow measurements and MRE were compared with those with SBE. RESULTS: The mean patient age was 15.0 years (range 11.3-18 years, 70% male). Of 14 patients with suspected IBD, 8 had a diagnosis of CD made after SBE. Activity in the small bowel was found in 14 patients (70%) with both suspected and previously diagnosed CD. Twelve patients (60%) had small-bowel disease that was out of reach of conventional endoscopy. Three patients (15%) had small-bowel activity solely in the jejunum, which was not detected by either MRE or US. LIMITATIONS: Single-center study with small sample size. CONCLUSIONS: SBE can be used in children to accurately assess small-bowel disease and CD. Small-bowel activity may be identified by SBE in some patients in whom it may not be apparent despite use of conventional upper endoscopy, ileocolonoscopy, US with Doppler flow measurements, or MRE.
Authors: Elsa A van Wassenaer; Floris A E de Voogd; Rick R van Rijn; Johanna H van Der Lee; Merit M Tabbers; Faridi S van Etten-Jamaludin; Krisztina B Gecse; Angelika Kindermann; Tim G J De Meij; Geert R D'haens; Marc A Benninga; Bart G P Koot Journal: J Crohns Colitis Date: 2019-12-10 Impact factor: 9.071
Authors: Giovanni Di Nardo; Gianluca Esposito; Chiara Ziparo; Federica Micheli; Luigi Masoni; Maria Pia Villa; Pasquale Parisi; Maria Beatrice Manca; Flavia Baccini; Vito Domenico Corleto Journal: World J Gastroenterol Date: 2020-10-21 Impact factor: 5.742
Authors: Giovanni Di Nardo; Carlo Calabrese; Roberto Conti Nibali; Arianna De Matteis; Emanuele Casciani; Luigi Martemucci; Giuseppe Pagliaro; Nico Pagano Journal: United European Gastroenterol J Date: 2018-07-12 Impact factor: 4.623