Literature DB >> 21962499

Genomics reaches the clinic: from basic discoveries to clinical impact.

Teri A Manolio1, Eric D Green.   

Abstract

Today, more than ever, basic science research provides significant opportunities to advance our understanding about the genetic basis of human disease. Close interactions among laboratory, computational, and clinical research communities will be crucial to ensure that genomic discoveries advance medical science and, ultimately, improve human health.
Copyright © 2011 Elsevier Inc. All rights reserved.

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Year:  2011        PMID： 21962499     DOI： 10.1016/j.cell.2011.09.012

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  16 in total

1.  A population approach to precision medicine.

Authors:  Muin J Khoury; Marta L Gwinn; Russell E Glasgow; Barnett S Kramer
Journal:  Am J Prev Med       Date:  2012-06       Impact factor: 5.043

Review 2.  Bringing genome-wide association findings into clinical use.

Authors:  Teri A Manolio
Journal:  Nat Rev Genet       Date:  2013-07-09       Impact factor: 53.242

Review 3.  Atherosclerosis, inflammation, genetics, and stem cells: 2012 update.

Authors:  Pascal J Goldschmidt-Clermont; Chunming Dong; David M Seo; Omaida C Velazquez
Journal:  Curr Atheroscler Rep       Date:  2012-06       Impact factor: 5.113

Review 4.  Clinical applications of age-related macular degeneration genetics.

Authors:  John Paul SanGiovanni; Emily Y Chew
Journal:  Cold Spring Harb Perspect Med       Date:  2014-08-14       Impact factor: 6.915

5.  PG4KDS: a model for the clinical implementation of pre-emptive pharmacogenetics.

Authors:  James M Hoffman; Cyrine E Haidar; Mark R Wilkinson; Kristine R Crews; Donald K Baker; Nancy M Kornegay; Wenjian Yang; Ching-Hon Pui; Ulrike M Reiss; Aditya H Gaur; Scott C Howard; William E Evans; Ulrich Broeckel; Mary V Relling
Journal:  Am J Med Genet C Semin Med Genet       Date:  2014-03-11       Impact factor: 3.908

6.  Physician Knowledge of Human Genetic Variation, Beliefs About Race and Genetics, and Use of Race in Clinical Decision-making.

Authors:  Sherrill L Sellers; Brooke A Cunningham; Vence L Bonham
Journal:  J Racial Ethn Health Disparities       Date:  2018-06-20

Review 7.  Prioritizing genomic applications for action by level of evidence: a horizon-scanning method.

Authors:  W D Dotson; M P Douglas; K Kolor; A C Stewart; M S Bowen; M Gwinn; A Wulf; H M Anders; C Q Chang; M Clyne; T K Lam; S D Schully; M Marrone; W G Feero; M J Khoury
Journal:  Clin Pharmacol Ther       Date:  2014-02-19       Impact factor: 6.875

Review 8.  Preemptive clinical pharmacogenetics implementation: current programs in five US medical centers.

Authors:  Henry M Dunnenberger; Kristine R Crews; James M Hoffman; Kelly E Caudle; Ulrich Broeckel; Scott C Howard; Robert J Hunkler; Teri E Klein; William E Evans; Mary V Relling
Journal:  Annu Rev Pharmacol Toxicol       Date:  2014-10-02       Impact factor: 13.820

9.  Merging Electronic Health Record Data and Genomics for Cardiovascular Research: A Science Advisory From the American Heart Association.

Authors:  Jennifer L Hall; John J Ryan; Bruce E Bray; Candice Brown; David Lanfear; L Kristin Newby; Mary V Relling; Neil J Risch; Dan M Roden; Stanley Y Shaw; James E Tcheng; Jessica Tenenbaum; Thomas N Wang; William S Weintraub
Journal:  Circ Cardiovasc Genet       Date:  2016-03-14

10.  Genetics in population health science: strategies and opportunities.

Authors:  Daniel W Belsky; Terrie E Moffitt; Avshalom Caspi
Journal:  Am J Public Health       Date:  2013-08-08       Impact factor: 9.308
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