BACKGROUND AND PURPOSE: Patients with DMD have demonstrated functional abnormalities in the motor-related brain areas in previous PET, MRS, and TMS studies. We applied structural MR imaging and RS-fMRI in patients with DMD for the first time, and aimed to investigate the GMC and ReHo or local synchronization of spontaneous activity in the motor cortex. MATERIALS AND METHODS: Ten boys with DMD (6.4-14.0 years of age) and 15 healthy controls (7.9-15.1 years of age) underwent brain structural MR imaging and RS-fMRI scanning. GMC and local synchronization of spontaneous activity in the motor cortex were analyzed by using VBM and ReHo approaches, respectively. RESULTS: Compared with healthy controls, boys with DMD showed decreased GMC in the left PSMC and decreased ReHo in the bilateral PMSC as well as in the supplementary motor area (P < .05, corrected). CONCLUSIONS: The current results indicate that boys with DMD have both GMC loss and decreased local synchronization of spontaneous activity in the motor cortex, which might be due to the deficiency of dystrophin in the brain.
BACKGROUND AND PURPOSE:Patients with DMD have demonstrated functional abnormalities in the motor-related brain areas in previous PET, MRS, and TMS studies. We applied structural MR imaging and RS-fMRI in patients with DMD for the first time, and aimed to investigate the GMC and ReHo or local synchronization of spontaneous activity in the motor cortex. MATERIALS AND METHODS: Ten boys with DMD (6.4-14.0 years of age) and 15 healthy controls (7.9-15.1 years of age) underwent brain structural MR imaging and RS-fMRI scanning. GMC and local synchronization of spontaneous activity in the motor cortex were analyzed by using VBM and ReHo approaches, respectively. RESULTS: Compared with healthy controls, boys with DMD showed decreased GMC in the left PSMC and decreased ReHo in the bilateral PMSC as well as in the supplementary motor area (P < .05, corrected). CONCLUSIONS: The current results indicate that boys with DMD have both GMCloss and decreased local synchronization of spontaneous activity in the motor cortex, which might be due to the deficiency of dystrophin in the brain.
Authors: M E Raichle; A M MacLeod; A Z Snyder; W J Powers; D A Gusnard; G L Shulman Journal: Proc Natl Acad Sci U S A Date: 2001-01-16 Impact factor: 11.205
Authors: Peter Schwenkreis; Michael Voigt; Monika Hasenbring; Martin Tegenthoff; Matthias Vorgerd; Rudolf A Kley Journal: Muscle Nerve Date: 2011-02-08 Impact factor: 3.217
Authors: V Di Lazzaro; D Restuccia; S Servidei; R Nardone; A Oliviero; P Profice; F Mangiola; P Tonali; J C Rothwell Journal: Muscle Nerve Date: 1998-05 Impact factor: 3.217
Authors: N Bresolin; E Castelli; G P Comi; G Felisari; A Bardoni; D Perani; F Grassi; A Turconi; F Mazzucchelli; D Gallotti Journal: Neuromuscul Disord Date: 1994-07 Impact factor: 4.296
Authors: V Preethish-Kumar; A Shah; M Kumar; M Ingalhalikar; K Polavarapu; M Afsar; J Rajeswaran; S Vengalil; S Nashi; P T Thomas; A Sadasivan; M Warrier; A Nalini; J Saini Journal: AJNR Am J Neuroradiol Date: 2020-07-02 Impact factor: 3.825
Authors: Nathalie Doorenweerd; Mischa de Rover; Chiara Marini-Bettolo; Kieren G Hollingsworth; Erik H Niks; Jos G M Hendriksen; Hermien E Kan; Volker Straub Journal: Brain Imaging Behav Date: 2021-01-03 Impact factor: 3.978