Literature DB >> 21959946

Facile synthesis and altered ionization efficiency of diverse Nε-alkyllysine-containing peptides.

Debjani Chakraborty1, Kabirul Islam, Minkui Luo.   

Abstract

Protein lysine methylation is a biologically-important posttranslational modification. Given the increased use of alkyllysine-containing peptides to study protein methylation, we describe an efficient solid-phase synthesis to access various alkyllysine-containing peptides. As an exemplary application, we evaluated how ionization efficiency of the alkyllysine peptides affects mass spectrometric analysis. This journal is © The Royal Society of Chemistry 2012

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Year:  2011        PMID： 21959946      PMCID： PMC3573693          DOI： 10.1039/c1cc14711k

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  18 in total

1.  Transcriptional coactivator protein p300. Kinetic characterization of its histone acetyltransferase activity.

Authors:  P R Thompson; H Kurooka; Y Nakatani; P A Cole
Journal:  J Biol Chem       Date:  2001-07-09       Impact factor: 5.157

2.  Reductive and catalytic monoalkylation of primary amines using nitriles as an alkylating reagent.

Authors:  Hironao Sajiki; Takashi Ikawa; Kosaku Hirota
Journal:  Org Lett       Date:  2004-12-23       Impact factor: 6.005

3.  Concise preparation of N(alpha)-Fmoc-N(epsilon)-(Boc, methyl)-lysine and its application in the synthesis of site-specifically lysine monomethylated peptide.

Authors:  Z-P Huang; J-T Du; X-Y Su; Y-X Chen; Y-F Zhao; Y-M Li
Journal:  Amino Acids       Date:  2006-10-13       Impact factor: 3.520

4.  SnapShot: Histone-modifying enzymes.

Authors:  Tony Kouzarides
Journal:  Cell       Date:  2007-02-23       Impact factor: 41.582

5.  Genotype analysis of the VNTR polymorphism in the SMYD3 histone methyltransferase gene: lack of correlation with the level of histone H3 methylation in NSCLC tissues or with the risk of NSCLC.

Authors:  Fabrice Barlési; Giuseppe Giaccone; Marielle I Gallegos-Ruiz; Simone W Span; Pierre Lefesvre; Frank A E Kruyt; Jose Antonio Rodriguez
Journal:  Int J Cancer       Date:  2008-03-15       Impact factor: 7.396

Review 6.  Chemical probes for histone-modifying enzymes.

Authors:  Philip A Cole
Journal:  Nat Chem Biol       Date:  2008-10       Impact factor: 15.040

Review 7.  Coordinated chromatin control: structural and functional linkage of DNA and histone methylation.

Authors:  Xiaodong Cheng; Robert M Blumenthal
Journal:  Biochemistry       Date:  2010-04-13       Impact factor: 3.162

8.  Comparative analysis of small molecules and histone substrate analogues as LSD1 lysine demethylase inhibitors.

Authors:  Jeffrey C Culhane; Dongqing Wang; Paul M Yen; Philip A Cole
Journal:  J Am Chem Soc       Date:  2010-03-10       Impact factor: 15.419

9.  Labeling substrates of protein arginine methyltransferase with engineered enzymes and matched S-adenosyl-L-methionine analogues.

Authors:  Rui Wang; Weihong Zheng; Haiqiang Yu; Haiteng Deng; Minkui Luo
Journal:  J Am Chem Soc       Date:  2011-05-03       Impact factor: 15.419

Review 10.  Chemical mechanisms of histone lysine and arginine modifications.

Authors:  Brian C Smith; John M Denu
Journal:  Biochim Biophys Acta       Date:  2008-06-14
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  2 in total

1.  Defining efficient enzyme-cofactor pairs for bioorthogonal profiling of protein methylation.

Authors:  Kabirul Islam; Yuling Chen; Hong Wu; Ian R Bothwell; Gil J Blum; Hong Zeng; Aiping Dong; Weihong Zheng; Jinrong Min; Haiteng Deng; Minkui Luo
Journal:  Proc Natl Acad Sci U S A       Date:  2013-09-30       Impact factor: 11.205

2.  Large-scale, protection-free synthesis of Se-adenosyl-L-selenomethionine analogues and their application as cofactor surrogates of methyltransferases.

Authors:  Ian R Bothwell; Minkui Luo
Journal:  Org Lett       Date:  2014-05-22       Impact factor: 6.005
  2 in total

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