Literature DB >> 21959761

Models of inflammation: adjuvant-induced arthritis in the rat.

P E Whiteley1, S A Dalrymple.   

Abstract

Injection of adjuvant (Mycobacterium butyricum suspended in mineral oil) into rats produces an immune reaction that characteristically involves inflammatory destruction of cartilage and bone of the distal joints with concomitant swelling of surrounding tissues. Adjuvant-induced arthritis in rats is commonly used to evaluate compounds that might be of potential use as drugs for treatment of rheumatoid arthritis and other chronic inflammatory conditions. This unit describes a method for inducing arthritis by injecting adjuvant into the tail and evaluating a test compound for the ability to inhibit the inflammatory response.

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Year:  2001        PMID： 21959761     DOI： 10.1002/0471141755.ph0505s13

Source DB:  PubMed          Journal:  Curr Protoc Pharmacol        ISSN： 1934-8282


  9 in total

Review 1.  Inducible nitric oxide synthase: Regulation, structure, and inhibition.

Authors:  Maris A Cinelli; Ha T Do; Galen P Miley; Richard B Silverman
Journal:  Med Res Rev       Date:  2019-06-13       Impact factor: 12.944

2.  Far infrared irradiation suppresses experimental arthritis in rats by down-regulation of genes involved inflammatory response and autoimmunity.

Authors:  Xi Chen; Hui Zhang; Wu Zeng; Nick Wang; Hang Hong Lo; Chi Kio Ip; Li Jun Yang; W L Wendy Hsiao; Wai Man Sin; Chenglai Xia; Betty Yuen Kwan Law; Vincent Kam Wai Wong
Journal:  J Adv Res       Date:  2021-09-01       Impact factor: 12.822

3.  The chemokine receptor CCR5 plays a role in post-traumatic cartilage loss in mice, but does not affect synovium and bone.

Authors:  K Takebe; M F Rai; E J Schmidt; L J Sandell
Journal:  Osteoarthritis Cartilage       Date:  2014-12-09       Impact factor: 6.576

4.  Topically applied phospho-sulindac hydrogel is efficacious and safe in the treatment of experimental arthritis in rats.

Authors:  George Mattheolabakis; Gerardo G Mackenzie; Liqun Huang; Nengtai Ouyang; Ka Wing Cheng; Basil Rigas
Journal:  Pharm Res       Date:  2013-03-13       Impact factor: 4.200

5.  Evaluation of Caesalpinia bonducella flower extract for anti-inflammatory action in rats and its high performance thin layer chromatography chemical fingerprinting.

Authors:  Rathinam Arunadevi; Shanmugam Murugammal; Dinesh Kumar; Surendra Kumar Tandan
Journal:  Indian J Pharmacol       Date:  2015 Nov-Dec       Impact factor: 1.200

6.  Topical Loperamide-Encapsulated Liposomal Gel Increases the Severity of Inflammation and Accelerates Disease Progression in the Adjuvant-Induced Model of Experimental Rheumatoid Arthritis.

Authors:  Susan Hua; Thilani H Dias; Debbie-Gai Pepperall; Yuan Yang
Journal:  Front Pharmacol       Date:  2017-08-02       Impact factor: 5.810

7.  Improvement of Pain Management by Nefopam in a Rat Adjuvant-Induced Arthritis Model.

Authors:  Elisa Dalix; Mathieu Maalouf; Marie-Thérèse Linossier; Arnaud Vanden-Bossche; Sylvie Peyroche; Hubert Marotte
Journal:  Front Vet Sci       Date:  2022-04-26

Review 8.  Natural Products for the Treatment of Autoimmune Arthritis: Their Mechanisms of Action, Targeted Delivery, and Interplay with the Host Microbiome.

Authors:  Steven Dudics; David Langan; Rakeshchandra R Meka; Shivaprasad H Venkatesha; Brian M Berman; Chun-Tao Che; Kamal D Moudgil
Journal:  Int J Mol Sci       Date:  2018-08-24       Impact factor: 5.923

Review 9.  Animal Models of Inflammation for Screening of Anti-inflammatory Drugs: Implications for the Discovery and Development of Phytopharmaceuticals.

Authors:  Kalpesh R Patil; Umesh B Mahajan; Banappa S Unger; Sameer N Goyal; Sateesh Belemkar; Sanjay J Surana; Shreesh Ojha; Chandragouda R Patil
Journal:  Int J Mol Sci       Date:  2019-09-05       Impact factor: 5.923
  9 in total

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