AIMS: The plasma protein growth arrest-specific 6 (Gas6) is important to the inflammatory process and involved in the development of diabetic renal and vascular complications. Recently, Gas6 protein also represents a novel independent risk factor of type 2 diabetes. We further investigated the association of c.843+7G>A Gas6 polymorphism and type 2 diabetes. METHODS: A total of 278 adults, including 96 with normal glucose tolerance (NGT), 82 with impaired glucose tolerance (IGT), and 100 with type 2 diabetes were recruited. All subjects were genotyped for c.843+7G>A Gas6 polymorphism. RESULTS: Plasma Gas6 concentrations were significantly lower among patients with type 2 diabetes compared to subjects with IGT and NGT. Subjects with Gas6 c.843+7AA genotype had higher Gas6 levels and lower glucose values than GG genotype. The AA genotype and A allele were less frequent in patients with type 2 diabetes compared with NGT subjects. In univariate analysis, the AA genotype was found to be associated with a decreased risk for type 2 diabetes. Moreover, the association was even stronger after adjustment for established diabetes risk factors. CONCLUSIONS: The Gas6 c.843+7AA genotype and A allele are less prevalent in type 2 diabetes, which may have a protective role for type 2 diabetes.
AIMS: The plasma protein growth arrest-specific 6 (Gas6) is important to the inflammatory process and involved in the development of diabetic renal and vascular complications. Recently, Gas6 protein also represents a novel independent risk factor of type 2 diabetes. We further investigated the association of c.843+7G>A Gas6 polymorphism and type 2 diabetes. METHODS: A total of 278 adults, including 96 with normal glucose tolerance (NGT), 82 with impaired glucose tolerance (IGT), and 100 with type 2 diabetes were recruited. All subjects were genotyped for c.843+7G>A Gas6 polymorphism. RESULTS: Plasma Gas6 concentrations were significantly lower among patients with type 2 diabetes compared to subjects with IGT and NGT. Subjects with Gas6 c.843+7AA genotype had higher Gas6 levels and lower glucose values than GG genotype. The AA genotype and A allele were less frequent in patients with type 2 diabetes compared with NGT subjects. In univariate analysis, the AA genotype was found to be associated with a decreased risk for type 2 diabetes. Moreover, the association was even stronger after adjustment for established diabetes risk factors. CONCLUSIONS: The Gas6 c.843+7AA genotype and A allele are less prevalent in type 2 diabetes, which may have a protective role for type 2 diabetes.
Authors: Gergely Losonczy; Attila Vajas; Lili Takács; Erika Dzsudzsák; Agnes Fekete; Eva Márhoffer; László Kardos; Eva Ajzner; Begoña Hurtado; Pablo Garcia de Frutos; András Berta; István Balogh Journal: PLoS One Date: 2012-11-29 Impact factor: 3.240
Authors: Pedro Recarte-Pelz; Dolors Tàssies; Gerard Espinosa; Begoña Hurtado; Núria Sala; Ricard Cervera; Joan Carles Reverter; Pablo García de Frutos Journal: Arthritis Res Ther Date: 2013-03-12 Impact factor: 5.156
Authors: Sarah Keildson; Joao Fadista; Claes Ladenvall; Åsa K Hedman; Targ Elgzyri; Kerrin S Small; Elin Grundberg; Alexandra C Nica; Daniel Glass; J Brent Richards; Amy Barrett; James Nisbet; Hou-Feng Zheng; Tina Rönn; Kristoffer Ström; Karl-Fredrik Eriksson; Inga Prokopenko; Timothy D Spector; Emmanouil T Dermitzakis; Panos Deloukas; Mark I McCarthy; Johan Rung; Leif Groop; Paul W Franks; Cecilia M Lindgren; Ola Hansson Journal: Diabetes Date: 2013-12-04 Impact factor: 9.461