OBJECTIVE: To explore the influence of HBV genotype on viral load in patients with HBV infection, and to investigate the relation to gender, age and country of origin or antibodies against hepatitis Be antigen (anti-HBe). MATERIALS: We investigated 1025 patients with hepatitis B virus infection in a nationwide study in Denmark. RESULTS: Prevalence of genotypes were: 10.5% A, 17.3% B, 20.5% C, 45.7% D, 3.2% E, 0.6% F, 1.1% G and 1% had more than one genotype. Nearly 60% of patients with genotype A were from Africa, 82% and 93% with genotypes B or C were from East Asia, 62% with genotype D came from the Middle East and 91% with genotype E came from Africa. More women had genotypes B (p = 0.006) or C (p < 0.001) while more men had genotypes A (p = 0.015) or D (p < 0.001). Women with genotypes B and D were younger than men (p < 0.001, p = 0.026). Viral load differed in genotype A and D compared with B and C (p < 0.001), and between anti-HBe and hepatitis B e antigen (HBeAg) positive patients (median values 5.4 × 10(3) IU/ml and 7.4 × 10(7) IU/ml, respectively, p < 0.001). Viral load depended on the presence of HBeAg (p < 0.001; OR, 95% CI: 0.05, 0.03-0.07) in the adjusted analysis and was not affected by origin (p = 0.65), age (p = 0.12), gender (p = 0.06) or genotype (p = 0.10). CONCLUSION: HBeAg status and not HBV genotype influenced viral load in this nationwide study. HBeAg positive patients had median HBV-DNA levels 10,000 times higher than those anti-HBe positive across genotypes.
OBJECTIVE: To explore the influence of HBV genotype on viral load in patients with HBV infection, and to investigate the relation to gender, age and country of origin or antibodies against hepatitis Be antigen (anti-HBe). MATERIALS: We investigated 1025 patients with hepatitis B virus infection in a nationwide study in Denmark. RESULTS: Prevalence of genotypes were: 10.5% A, 17.3% B, 20.5% C, 45.7% D, 3.2% E, 0.6% F, 1.1% G and 1% had more than one genotype. Nearly 60% of patients with genotype A were from Africa, 82% and 93% with genotypes B or C were from East Asia, 62% with genotype D came from the Middle East and 91% with genotype E came from Africa. More women had genotypes B (p = 0.006) or C (p < 0.001) while more men had genotypes A (p = 0.015) or D (p < 0.001). Women with genotypes B and D were younger than men (p < 0.001, p = 0.026). Viral load differed in genotype A and D compared with B and C (p < 0.001), and between anti-HBe and hepatitis B e antigen (HBeAg) positive patients (median values 5.4 × 10(3) IU/ml and 7.4 × 10(7) IU/ml, respectively, p < 0.001). Viral load depended on the presence of HBeAg (p < 0.001; OR, 95% CI: 0.05, 0.03-0.07) in the adjusted analysis and was not affected by origin (p = 0.65), age (p = 0.12), gender (p = 0.06) or genotype (p = 0.10). CONCLUSION:HBeAg status and not HBV genotype influenced viral load in this nationwide study. HBeAg positive patients had median HBV-DNA levels 10,000 times higher than those anti-HBe positive across genotypes.
Authors: Chloe L Thio; Laura Smeaton; Melissa Saulynas; Hyon Hwang; Shanmugam Saravanan; Shanmugam Saravan; Smita Kulkarni; James Hakim; Mulinda Nyirenda; Hussain S Iqbal; Umesh G Lalloo; Anand S Mehta; Kimberly Hollabaugh; Thomas B Campbell; Shahin Lockman; Judith S Currier Journal: AIDS Date: 2013-01-14 Impact factor: 4.177
Authors: Motswedi Anderson; Simani Gaseitsiwe; Sikhulile Moyo; Kerapetse P Thami; Terence Mohammed; Ditiro Setlhare; Theresa K Sebunya; Eleanor A Powell; Joseph Makhema; Jason T Blackard; Richard Marlink; Max Essex; Rosemary M Musonda Journal: Open Forum Infect Dis Date: 2016-08-16 Impact factor: 3.835
Authors: David FitzSimons; Brian McMahon; Greet Hendrickx; Alex Vorsters; Pierre Van Damme Journal: Int J Circumpolar Health Date: 2013-07-17 Impact factor: 1.228
Authors: Bo Langhoff Hønge; Sanne Jespersen; Candida Medina; David da Silva Té; Zacarias José da Silva; Sharon Lewin; Lars Østergaard; Christian Erikstrup; Christian Wejse; Alex Lund Laursen; Henrik Krarup Journal: PLoS One Date: 2014-06-10 Impact factor: 3.240