| Literature DB >> 21957865 |
Ioulia Gorokhovik1, Luc Neuville, Jieping Zhu.
Abstract
Ketoanilides containing alkyl side chains were readily cyclized to 3-hydroxy-2-oxindoles or spirooxindoles by a single or double intramolecular Friedel-Crafts reaction in the presence of trifluoroacetic acid (TFA) at room temperature or at 45 °C. α-Iminocarboxamides, generated in situ from ketoamides, cyclized similarly to 3-aminooxindoles under identical conditions.Entities:
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Year: 2011 PMID： 21957865 DOI： 10.1021/ol202263a
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005