Literature DB >> 21956679

[Update on HPV-induced oropharyngeal cancer].

S F Preuss1, J-P Klussmann, R Semrau, C Huebbers.   

Abstract

Oropharyngeal squamous cell carcinoma (OSCC) is associated with oncogenic human papillomavirus (HPV) infection in 30-40% of all cases in Germany. The use of PCR and / or in situ hybridisation to detect HPV in tumour tissue is used in combination with p16 immunohistochemistry to reliably distinguish HPV-related and HPV-unrelated OSCC. The distinct biological behaviour of the HPV-related subset of OSCC results in a more favourable prognosis. This might be the result of a greater response to chemotherapy and radiotherapy as seen in recent studies. Ongoing and future clinical trials will stratify for HPV status. If the results of these prospective, randomized trials are consistent with the preliminary results of recent studies, HPV status will be of enormous clinical relevance in the future.

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Year:  2011        PMID： 21956679     DOI： 10.1007/s00106-011-2391-z

Source DB:  PubMed          Journal:  HNO        ISSN： 0017-6192            Impact factor:   1.284


  19 in total

Review 1.  HPV-associated head and neck cancer: a virus-related cancer epidemic.

Authors:  Shanthi Marur; Gypsyamber D'Souza; William H Westra; Arlene A Forastiere
Journal:  Lancet Oncol       Date:  2010-05-05       Impact factor: 41.316

2.  Cetuximab and radiotherapy for head and neck cancer.

Authors:  Marshall R Posner; Lori J Wirth
Journal:  N Engl J Med       Date:  2006-02-09       Impact factor: 91.245

3.  Prevalence, distribution, and viral load of human papillomavirus 16 DNA in tonsillar carcinomas.

Authors:  J P Klussmann; S J Weissenborn; U Wieland; V Dries; J Kolligs; M Jungehuelsing; H E Eckel; H P Dienes; H J Pfister; P G Fuchs
Journal:  Cancer       Date:  2001-12-01       Impact factor: 6.860

Review 4.  The molecular biology of head and neck cancer.

Authors:  C René Leemans; Boudewijn J M Braakhuis; Ruud H Brakenhoff
Journal:  Nat Rev Cancer       Date:  2010-12-16       Impact factor: 60.716

5.  Molecular classification identifies a subset of human papillomavirus--associated oropharyngeal cancers with favorable prognosis.

Authors:  Paul M Weinberger; Ziwei Yu; Bruce G Haffty; Diane Kowalski; Malini Harigopal; Janet Brandsma; Clarence Sasaki; John Joe; Robert L Camp; David L Rimm; Amanda Psyrri
Journal:  J Clin Oncol       Date:  2006-01-09       Impact factor: 44.544

6.  Comparative prognostic value of HPV16 E6 mRNA compared with in situ hybridization for human oropharyngeal squamous carcinoma.

Authors:  Wei Shi; Hisayuki Kato; Bayardo Perez-Ordonez; Melania Pintilie; Shaohui Huang; Angela Hui; Brian O'Sullivan; John Waldron; Bernard Cummings; John Kim; Jolie Ringash; Laura A Dawson; Patrick Gullane; Lillian Siu; Maura Gillison; Fei-Fei Liu
Journal:  J Clin Oncol       Date:  2009-11-02       Impact factor: 44.544

7.  Improved survival of patients with human papillomavirus-positive head and neck squamous cell carcinoma in a prospective clinical trial.

Authors:  Carole Fakhry; William H Westra; Sigui Li; Anthony Cmelak; John A Ridge; Harlan Pinto; Arlene Forastiere; Maura L Gillison
Journal:  J Natl Cancer Inst       Date:  2008-02-12       Impact factor: 13.506

8.  Chemoselection as a strategy for organ preservation in advanced oropharynx cancer: response and survival positively associated with HPV16 copy number.

Authors:  Francis P Worden; Bhavna Kumar; Julia S Lee; Gregory T Wolf; Kitrina G Cordell; Jeremy M G Taylor; Susan G Urba; Avraham Eisbruch; Theodoros N Teknos; Douglas B Chepeha; Mark E Prince; Christina I Tsien; Nisha J D'Silva; Kun Yang; David M Kurnit; Heidi L Mason; Tamara H Miller; Nancy E Wallace; Carol R Bradford; Thomas E Carey
Journal:  J Clin Oncol       Date:  2008-05-12       Impact factor: 44.544

9.  Oral sexual behaviors associated with prevalent oral human papillomavirus infection.

Authors:  Gypsyamber D'Souza; Yuri Agrawal; Jane Halpern; Sacared Bodison; Maura L Gillison
Journal:  J Infect Dis       Date:  2009-05-01       Impact factor: 5.226

10.  Age, sexual behavior and human papillomavirus infection in oral cavity and oropharyngeal cancers.

Authors:  Elaine M Smith; Justine M Ritchie; Kurt F Summersgill; Jens P Klussmann; John H Lee; Donghong Wang; Thomas H Haugen; Lubomir P Turek
Journal:  Int J Cancer       Date:  2004-02-20       Impact factor: 7.396
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  4 in total

1.  [HPV infection in oral, pharyngeal and laryngeal papillomas].

Authors:  M Andratschke; H Hagedorn; A G Nerlich
Journal:  HNO       Date:  2015-11       Impact factor: 1.284

2.  [Human papillomavirus in squamous cell cancer of the head and neck. A study at the Ulm Military Hospital, Germany].

Authors:  M Maier; K Kraft; K Steinestel; A Schramm; K J Lorenz; M Tisch; M Schwerer; H Maier
Journal:  HNO       Date:  2013-07       Impact factor: 1.284

3.  [New aspects of HPV-positive head and neck cancer. Highlights from the 2011 ASCO Congress].

Authors:  B Kofler; F C Uecker; A Muenscher; R Knecht
Journal:  HNO       Date:  2012-05       Impact factor: 1.284

4.  Valosin-containing protein (VCP/p97)-expression correlates with prognosis of HPV- negative oropharyngeal squamous cell carcinoma (OSCC).

Authors:  Moritz F Meyer; Inga M C Seuthe; Uta Drebber; Oliver Siefer; Matthias Kreppel; Marcus O Klein; Stefanie Mikolajczak; Jens Peter Klussmann; Simon F Preuss; Christian U Huebbers
Journal:  PLoS One       Date:  2014-12-02       Impact factor: 3.240
  4 in total

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