OBJECTIVES: We aimed at synchronously examining the early time course of 4 proinflammatory cytokines as predictive factors for development of organ failure in patients with acute pancreatitis (AP). METHODS: Interleukin (IL) 6, IL-8, IL-18, and tumor necrosis factor α were measured on admission and at days 1, 2, and 14 in 60 patients admitted with first attack of AP. The prediction of single-organ and multiorgan failure from the cytokine profiles was evaluated by receiver operating characteristic analyses. RESULTS: Interleukin 6 and IL-8 levels were significantly higher in patients who developed renal, respiratory, and circulatory failure, as was the case for patients with multiorgan failure. Interleukin 18 levels were significantly elevated in renal and respiratory failure only. Tumor necrosis factor α was significantly elevated in all types of organ failures, except for intestinal failure. CONCLUSIONS: Synchronous measurements of 4 cytokines demonstrated IL-6 and IL-8 to be predictive as early surrogate markers with regard to organ failures in AP. The fact that all of the cytokines were particularly elevated in patients with organ failures calls for evaluation of agents modifying the severe inflammatory response in patients with AP.
OBJECTIVES: We aimed at synchronously examining the early time course of 4 proinflammatory cytokines as predictive factors for development of organ failure in patients with acute pancreatitis (AP). METHODS:Interleukin (IL) 6, IL-8, IL-18, and tumor necrosis factor α were measured on admission and at days 1, 2, and 14 in 60 patients admitted with first attack of AP. The prediction of single-organ and multiorgan failure from the cytokine profiles was evaluated by receiver operating characteristic analyses. RESULTS:Interleukin 6 and IL-8 levels were significantly higher in patients who developed renal, respiratory, and circulatory failure, as was the case for patients with multiorgan failure. Interleukin 18 levels were significantly elevated in renal and respiratory failure only. Tumor necrosis factor α was significantly elevated in all types of organ failures, except for intestinal failure. CONCLUSIONS: Synchronous measurements of 4 cytokines demonstrated IL-6 and IL-8 to be predictive as early surrogate markers with regard to organ failures in AP. The fact that all of the cytokines were particularly elevated in patients with organ failures calls for evaluation of agents modifying the severe inflammatory response in patients with AP.
Authors: Emmanuel I González-Moreno; José A González-González; Elvira Garza-González; Francisco J Bosques-Padilla; Héctor J Maldonado-Garza Journal: Am J Gastroenterol Date: 2016-01 Impact factor: 10.864
Authors: Hong Zhang; Patrick Neuhöfer; Liang Song; Björn Rabe; Marina Lesina; Magdalena U Kurkowski; Matthias Treiber; Thomas Wartmann; Sara Regnér; Henrik Thorlacius; Dieter Saur; Gregor Weirich; Akihiko Yoshimura; Walter Halangk; Joseph P Mizgerd; Roland M Schmid; Stefan Rose-John; Hana Algül Journal: J Clin Invest Date: 2013-02-15 Impact factor: 14.808
Authors: Abdullah Ozkok; Omer Celal Elcioglu; Tahsin Cukadar; Ali Bakan; Gulsah Sasak; Kadir Gokhan Atilgan; Sabahat Alisir; Mehmet Kanbay; Adrian Covic; Ali Riza Odabas Journal: Int Urol Nephrol Date: 2012-08-02 Impact factor: 2.370