Literature DB >> 21955259

Cannabinoid-1 receptor antagonist rimonabant (SR141716) increases striatal dopamine D2 receptor availability.

Cleo L Crunelle1, Elsmarieke van de Giessen, Sybille Schulz, Louk J M J Vanderschuren, Kora de Bruin, Wim van den Brink, Jan Booij.   

Abstract

The cannabinoid 1 receptor antagonist rimonabant (SR141716) alters rewarding properties and intake of food and drugs. Additionally, striatal dopamine D2 receptor (DRD2) availability has been implicated in reward function. This study shows that chronic treatment of rats with rimonabant (1.0 and 3.0 mg/kg/day) dose-dependently increased DRD2 availability in the dorsal striatum (14 and 23%) compared with vehicle. High-dose rimonabant also increased DRD2 availability in the ventral striatum (12%) and reduced weight gain. Thus, up-regulation of striatal DRD2 by chronic rimonabant administration may be an underlying mechanism of action and confirms the interactions of the endocannabinoid and dopaminergic systems.
© 2011 The Authors, Addiction Biology © 2011 Society for the Study of Addiction.

Entities:  

Keywords:  Cannabinoid 1 receptor; IBZM; dopamine D2 receptor; nucleus accumbens; rimonabant; striatum

Mesh：

Substances：

Year:  2011        PMID： 21955259      PMCID： PMC3252421          DOI： 10.1111/j.1369-1600.2011.00369.x

Source DB:  PubMed          Journal:  Addict Biol        ISSN： 1355-6215            Impact factor:   4.280


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