BACKGROUND: Few population-based studies of infectious etiologies of fever-rash illnesses have been conducted. This study reports on enhanced febrile-rash illness surveillance in Campinas, Brazil, a setting of low measles and rubella virus transmission. METHODS: Cases of febrile-rash illnesses in individuals aged <40 years that occurred during the period 1 May 2003-30 May 2004 were reported. Blood samples were collected for laboratory diagnostic confirmation, which included testing for adenovirus, dengue virus, Epstein-Barr virus (EBV), enterovirus, human herpes virus 6 (HHV6), measles virus, parvovirus-B19, Rickettsia rickettsii, rubella virus, and group A streptococci (GAS) infections. Notification rates were compared with the prestudy period. RESULTS: A total of 1248 cases were notified, of which 519 (42%) had laboratory diagnosis. Of these, HHV-6 (312 cases), EBV (66 cases), parvovirus (30 cases), rubella virus (30 cases), and GAS (30 cases) were the most frequent causes of infection. Only 10 rubella cases met the rubella clinical case definition currently in use. Notification rates were higher during the study than in the prestudy period (181 vs 52.3 cases per 100,000 population aged <40 years). CONCLUSIONS: Stimulating a passive surveillance system enhanced its sensitivity and resulted in additional rubella cases detected. In settings with rubella elimination goals, rubella testing may be considered for all cases of febrile-rash illness, regardless of suspected clinical diagnosis.
BACKGROUND: Few population-based studies of infectious etiologies of fever-rash illnesses have been conducted. This study reports on enhanced febrile-rash illness surveillance in Campinas, Brazil, a setting of low measles and rubella virus transmission. METHODS: Cases of febrile-rash illnesses in individuals aged <40 years that occurred during the period 1 May 2003-30 May 2004 were reported. Blood samples were collected for laboratory diagnostic confirmation, which included testing for adenovirus, dengue virus, Epstein-Barr virus (EBV), enterovirus, human herpes virus 6 (HHV6), measles virus, parvovirus-B19, Rickettsia rickettsii, rubella virus, and group A streptococci (GAS) infections. Notification rates were compared with the prestudy period. RESULTS: A total of 1248 cases were notified, of which 519 (42%) had laboratory diagnosis. Of these, HHV-6 (312 cases), EBV (66 cases), parvovirus (30 cases), rubella virus (30 cases), and GAS (30 cases) were the most frequent causes of infection. Only 10 rubella cases met the rubella clinical case definition currently in use. Notification rates were higher during the study than in the prestudy period (181 vs 52.3 cases per 100,000 population aged <40 years). CONCLUSIONS: Stimulating a passive surveillance system enhanced its sensitivity and resulted in additional rubella cases detected. In settings with rubella elimination goals, rubella testing may be considered for all cases of febrile-rash illness, regardless of suspected clinical diagnosis.
Authors: Marina A Yermalovich; Alina M Dronina; Galina V Semeiko; Elena O Samoilovich; Vladislav V Khrustalev; Aurelie Sausy; Judith M Hübschen Journal: Sci Rep Date: 2021-01-13 Impact factor: 4.379
Authors: Marina A Yermalovich; Galina V Semeiko; Elena O Samoilovich; Ekaterina Y Svirchevskaya; Claude P Muller; Judith M Hübschen Journal: PLoS One Date: 2014-10-30 Impact factor: 3.240
Authors: Tony Bokalanga Wawina; Olivier Mbaya Tshiani; Steve Mundeke Ahuka; Elisabeth Simbu Pukuta; Michel Ntetani Aloni; Christopher Jacob Kasanga; Jean-Jacques Tamfum Muyembe Journal: Int J Infect Dis Date: 2017-09-22 Impact factor: 3.623
Authors: Maria Isabel de Oliveira; Gislene Mitsue Namiyama; Gabriela Bastos Cabral; João Leandro Ferreira; Noemi Taniwaki; Ana Maria Sardinha Afonso; Isabella Rillo Lima; Luís Fernando Macedo de Brigido Journal: Rev Inst Med Trop Sao Paulo Date: 2018-03-08 Impact factor: 1.846