Literature DB >> 21954061

Development of highly cytotoxic and actin-depolymerizing biotin derivatives of aplyronine A.

Masaki Kita1, Yuichiro Hirayama, Miyuki Sugiyama, Hideo Kigoshi.   

Abstract

Tied up: a PEG-linked biotin derivative of marine macrolide aplyronine A (ApA) is shown to exhibit potent cytotoxicity and cause actin disassembly in tumor cells. This method of introducing a PEG linker at the end of the aliphatic tail should offer perspectives for developing and using versatile actin-targeting molecular probes. PEG=poly(ethylene glycol).
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Year:  2011        PMID： 21954061     DOI： 10.1002/anie.201103802

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  5 in total

Review 1.  Marine Mollusk-Derived Agents with Antiproliferative Activity as Promising Anticancer Agents to Overcome Chemotherapy Resistance.

Authors:  Maria Letizia Ciavatta; Florence Lefranc; Marianna Carbone; Ernesto Mollo; Margherita Gavagnin; Tania Betancourt; Ramesh Dasari; Alexander Kornienko; Robert Kiss
Journal:  Med Res Rev       Date:  2016-12-07       Impact factor: 12.944

Review 2.  Bioactive Compounds from Marine Heterobranchs.

Authors:  Conxita Avila; Carlos Angulo-Preckler
Journal:  Mar Drugs       Date:  2020-12-21       Impact factor: 5.118

3.  A quantitative chemical proteomics approach to profile the specific cellular targets of andrographolide, a promising anticancer agent that suppresses tumor metastasis.

Authors:  Jigang Wang; Xing Fei Tan; Van Sang Nguyen; Peng Yang; Jing Zhou; Mingming Gao; Zhengjun Li; Teck Kwang Lim; Yingke He; Chye Sun Ong; Yifei Lay; Jianbin Zhang; Guili Zhu; Siew-Li Lai; Dipanjana Ghosh; Yu Keung Mok; Han-Ming Shen; Qingsong Lin
Journal:  Mol Cell Proteomics       Date:  2014-01-20       Impact factor: 5.911

4.  Total synthesis of aplyronine C.

Authors:  Ian Paterson; Sarah J Fink; Lydia Y W Lee; Stephen J Atkinson; Simon B Blakey
Journal:  Org Lett       Date:  2013-06-03       Impact factor: 6.005

5.  6-Amidopyrene as a label-assisted laser desorption/ionization (LA-LDI) enhancing tag: development of photoaffinity pyrene derivative.

Authors:  Kozo Yoneda; Yaping Hu; Masaki Kita; Hideo Kigoshi
Journal:  Sci Rep       Date:  2015-12-15       Impact factor: 4.379
  5 in total

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