Literature DB >> 21954017

Novel rhein analogues as potential anticancer agents.

Xiaochuan Yang1, Guojing Sun, Chunhao Yang, Binghe Wang.   

Abstract

Two series of rhein analogues were synthesized with modification at the 3-position. Their cytotoxicities were evaluated using an MTT assay. Among all the compounds synthesized, one compound showed the best potency, with an IC(50) value of 2.7 μM against the HeLa cell line and 0.6 μM against the MOLT4 cell line.
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Year:  2011        PMID： 21954017     DOI： 10.1002/cmdc.201100384

Source DB:  PubMed          Journal:  ChemMedChem        ISSN： 1860-7179            Impact factor:   3.466


  13 in total

1.  Inducing Apoptosis through Upregulation of p53: Structure-Activity Exploration of Anthraquinone Analogs.

Authors:  Abiodun Anifowose; Ayodeji A Agbowuro; Ravi Tripathi; Wen Lu; Chalet Tan; Xiaoxiao Yang; Binghe Wang
Journal:  Med Chem Res       Date:  2020-06-07       Impact factor: 1.965

2.  Inhibition of MDM2 by a Rhein-Derived Compound AQ-101 Suppresses Cancer Development in SCID Mice.

Authors:  Lubing Gu; Hailong Zhang; Tao Liu; Alexander Draganov; Sha Yi; Binghe Wang; Muxiang Zhou
Journal:  Mol Cancer Ther       Date:  2017-12-27       Impact factor: 6.261

3.  Novel Anthraquinone Compounds Induce Cancer Cell Death through Paraptosis.

Authors:  Wei Tian; Junying Li; Zhengying Su; Fu Lan; Zhaoquan Li; Dandan Liang; Chunmiao Wang; Danrong Li; Huaxin Hou
Journal:  ACS Med Chem Lett       Date:  2019-03-25       Impact factor: 4.345

4.  Upregulation of p53 through induction of MDM2 degradation: Amino acid prodrugs of anthraquinone analogs.

Authors:  Abiodun Anifowose; Zhengnan Yuan; Xiaoxiao Yang; Zhixiang Pan; Yueqin Zheng; Zhongwei Zhang; Binghe Wang
Journal:  Bioorg Med Chem Lett       Date:  2019-11-11       Impact factor: 2.823

5.  Rhein, a natural anthraquinone derivative, attenuates the activation of pancreatic stellate cells and ameliorates pancreatic fibrosis in mice with experimental chronic pancreatitis.

Authors:  Siu Wai Tsang; Hongjie Zhang; Chengyuan Lin; Haitao Xiao; Michael Wong; Hongcai Shang; Zhi-Jun Yang; Aiping Lu; Ken Kin-Lam Yung; Zhaoxiang Bian
Journal:  PLoS One       Date:  2013-12-03       Impact factor: 3.240

6.  Transition-Metal-Free Decarboxylative Iodination: New Routes for Decarboxylative Oxidative Cross-Couplings.

Authors:  Gregory J P Perry; Jacob M Quibell; Adyasha Panigrahi; Igor Larrosa
Journal:  J Am Chem Soc       Date:  2017-08-08       Impact factor: 15.419

7.  Convenient Synthesis of 6,7,12,13-Tetrahydro-5H-Cyclohepta[2,1-b:3,4-b']diindole Derivatives Mediated by Hypervalent Iodine (III) Reagent.

Authors:  Lei Peng; Xiaofei Zhang; Chunhao Yang
Journal:  Molecules       Date:  2019-03-08       Impact factor: 4.411

8.  Anti-fibrotic effects of phenolic compounds on pancreatic stellate cells.

Authors:  Zesi Lin; Lu-Cong Zheng; Hong-Jie Zhang; Siu Wai Tsang; Zhao-Xiang Bian
Journal:  BMC Complement Altern Med       Date:  2015-07-30       Impact factor: 3.659

9.  Discovery of Novel Allopurinol Derivatives with Anticancer Activity and Attenuated Xanthine Oxidase Inhibition.

Authors:  Yong Li; Ting-Ting Cao; Shanchun Guo; Qiu Zhong; Cai-Hu Li; Ying Li; Lin Dong; Shilong Zheng; Guangdi Wang; Shu-Fan Yin
Journal:  Molecules       Date:  2016-06-20       Impact factor: 4.411

Review 10.  Herbal remedies for liver fibrosis: A review on the mode of action of fifty herbs.

Authors:  Uzma Latief; Riaz Ahmad
Journal:  J Tradit Complement Med       Date:  2017-11-22
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