PURPOSE: To investigate age-related regional perfusion changes focused on the medial temporal lobes and related parietal areas using a pulsed arterial spin labeling technique. MATERIALS AND METHODS: Resting cerebral blood flow (CBF) maps were obtained from 44 healthy volunteers (18 male, 26 female; age range, 19 to 79 years) using a pulsed arterial spin labeling (PASL) MRI technique at 3 Tesla focused on the parietal and temporal lobes. Repeated measurements were performed in 20 subjects to assure the reliability and reproducibility of the applied PASL technique. RESULTS: Focal age-related CBF decreases were detected in the parietal cortex, cuneus and caudate, whereas increases were seen in the lateral and medial temporal lobe such as hippocampus, the calcarine gyrus and the thalamus. Moreover, repeated measurements demonstrated a high reliability and reproducibility of the applied PASL technique. CONCLUSION: Data provide evidence for regionally dissociated patterns of perfusion increases and decreases during ageing in the temporal and parietal lobes.
PURPOSE: To investigate age-related regional perfusion changes focused on the medial temporal lobes and related parietal areas using a pulsed arterial spin labeling technique. MATERIALS AND METHODS: Resting cerebral blood flow (CBF) maps were obtained from 44 healthy volunteers (18 male, 26 female; age range, 19 to 79 years) using a pulsed arterial spin labeling (PASL) MRI technique at 3 Tesla focused on the parietal and temporal lobes. Repeated measurements were performed in 20 subjects to assure the reliability and reproducibility of the applied PASL technique. RESULTS: Focal age-related CBF decreases were detected in the parietal cortex, cuneus and caudate, whereas increases were seen in the lateral and medial temporal lobe such as hippocampus, the calcarine gyrus and the thalamus. Moreover, repeated measurements demonstrated a high reliability and reproducibility of the applied PASL technique. CONCLUSION: Data provide evidence for regionally dissociated patterns of perfusion increases and decreases during ageing in the temporal and parietal lobes.
Authors: Jens Göttler; Christine Preibisch; Isabelle Riederer; Lorenzo Pasquini; Panagiotis Alexopoulos; Karl Peter Bohn; Igor Yakushev; Ebba Beller; Stephan Kaczmarz; Claus Zimmer; Timo Grimmer; Alexander Drzezga; Christian Sorg Journal: J Cereb Blood Flow Metab Date: 2018-02-12 Impact factor: 6.200
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Authors: Stefano Trebeschi; Isabelle Riederer; Christine Preibisch; Karl P Bohn; Stefan Förster; Panagiotis Alexopoulos; Claus Zimmer; Jan S Kirschke; Alexander Valentinitsch Journal: Front Neurosci Date: 2016-04-19 Impact factor: 4.677