| Literature DB >> 2195337 |
K D Sugden1, R B Burris, S J Rogers.
Abstract
Evidence is provided that mutagenicity in Salmonella by a chromium(VI) salt and a chromium(III) compound has a differential dependence on the presence of oxygen. The mutagenic chromium(III) compound, cis-dichlorobis(2,2'-bipyridyl)chromium(III), reverted Salmonella strains, TA102 and TA2638, only under aerobic conditions. Potassium dichromate (chromium VI) required the presence of oxygen to revert the Salmonella strain TA102 but induced a moderate reversion frequency in TA2638 under anaerobic conditions. The data also support a role for oxygen radicals in chromium-mediated mutagenesis and suggests at least two pathways by which chromium compounds can induce mutations.Entities:
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Year: 1990 PMID： 2195337 DOI： 10.1016/0165-7992(90)90135-7
Source DB: PubMed Journal: Mutat Res ISSN： 0027-5107 Impact factor: 2.433