OBJECTIVE: Undifferentiated arthritis (UA) is a diagnosis 'per exclusionem'. Therefore this patient population may change since the development of the ACR/EULAR 2010-criteria for RA. This study evaluated characteristics and outcomes of UA in its new shape. Second, it was evaluated whether the 2010-criteria and the Leiden prediction rule were congruent in categorizing UA-patients. METHODS: 2,472 early arthritis patients were studied. RA was classified according to either the 1987 or the 2010-criteria. UA was defined as not fulfilling existing classification criteria. UA-patients were compared for baseline characteristics and outcomes. In 1987-UA-patients both the 2010-criteria and the Leiden prediction rule were applied and categorization compared. RESULTS: 2010-UA-patients (n=776) had milder baseline characteristics than 1987-UA-patients (n=1,166). During follow-up, still 24% of the 2010-UA-patients fulfilled the 1987 RA-criteria compared to 32% of the 1987-UA-patients. The 2010-UA-patients started less frequent DMARD-therapy and reached more frequent sustained DMARD-free remission. 30% of 2010-criteria-positive patients were predicted to have a low risk on RA; these patients achieved more frequent DMARD-free sustained remission than other 2010-criteria-positive patients. CONCLUSION: UA in the era of the 2010-criteria is less prevalent and milder at presentation and in outcome. This implies that UA-patients with unfavorable characteristics are now more often classified as RA.
OBJECTIVE: Undifferentiated arthritis (UA) is a diagnosis 'per exclusionem'. Therefore this patient population may change since the development of the ACR/EULAR 2010-criteria for RA. This study evaluated characteristics and outcomes of UA in its new shape. Second, it was evaluated whether the 2010-criteria and the Leiden prediction rule were congruent in categorizing UA-patients. METHODS: 2,472 early arthritispatients were studied. RA was classified according to either the 1987 or the 2010-criteria. UA was defined as not fulfilling existing classification criteria. UA-patients were compared for baseline characteristics and outcomes. In 1987-UA-patients both the 2010-criteria and the Leiden prediction rule were applied and categorization compared. RESULTS: 2010-UA-patients (n=776) had milder baseline characteristics than 1987-UA-patients (n=1,166). During follow-up, still 24% of the 2010-UA-patients fulfilled the 1987 RA-criteria compared to 32% of the 1987-UA-patients. The 2010-UA-patients started less frequent DMARD-therapy and reached more frequent sustained DMARD-free remission. 30% of 2010-criteria-positive patients were predicted to have a low risk on RA; these patients achieved more frequent DMARD-free sustained remission than other 2010-criteria-positive patients. CONCLUSION:UA in the era of the 2010-criteria is less prevalent and milder at presentation and in outcome. This implies that UA-patients with unfavorable characteristics are now more often classified as RA.
Authors: Saida Farah Issa; Anne Duer; Mikkel Østergaard; Kim Hørslev-Petersen; Merete L Hetland; Michael Sejer Hansen; Kirsten Junker; Hanne M Lindegaard; Jakob M Møller; Peter Junker Journal: Arthritis Res Ther Date: 2017-04-26 Impact factor: 5.156
Authors: Iuliia Biliavska; Tanja A Stamm; Jose Martinez-Avila; Thomas W J Huizinga; Robert B M Landewé; Günter Steiner; Daniel Aletaha; Josef S Smolen; Klaus P Machold Journal: Ann Rheum Dis Date: 2012-09-15 Impact factor: 19.103
Authors: Jens K Pedersen; Tove Lorenzen; Bo Ejbjerg; Marcin Szkudlarek; Anne Voss; Mikkel Østergaard; Anders J Svendsen; Lis S Andersen; Kim Hørslev-Petersen Journal: BMC Musculoskelet Disord Date: 2014-08-07 Impact factor: 2.362
Authors: Amy E Anderson; Arthur G Pratt; Mamdouh A K Sedhom; John Paul Doran; Christine Routledge; Ben Hargreaves; Philip M Brown; Kim-Anh Lê Cao; John D Isaacs; Ranjeny Thomas Journal: Ann Rheum Dis Date: 2015-02-03 Impact factor: 19.103