BACKGROUND: Both familial and sporadic Alzheimer's disease (AD) result in progressive cortical and subcortical atrophy. Familial autosomal dominant AD (FAD) allows us to study AD brain changes presymptomatically. METHODS: 33 subjects at risk for FAD (25 for PSEN1 and 8 for APP mutations; 22 mutation carriers and 11 controls) and 3 demented PSEN1 mutation carriers underwent T(1)-weighted MPRAGE 1.5T MRI. Using the hippocampal radial distance and cortical pattern matching techniques, we investigated the effects of carrier status and dementia diagnosis on cortical and hippocampal atrophy. All analyses were corrected for age and relative age (years to median age of disease onset in the family). RESULTS: The dementia cases had pronounced cortical atrophy in the lateral and medial parietal, posterior cingulate and frontal cortices and hippocampal atrophy bilaterally relative to both nondemented carriers and controls. Nondemented carriers did not show significant cortical thinning or hippocampal atrophy relative to controls. CONCLUSIONS: FAD is associated with thinning of the posterior association and frontal cortices and hippocampal atrophy. Larger sample sizes may be necessary to reliably identify cortical atrophy in presymptomatic carriers.
BACKGROUND: Both familial and sporadic Alzheimer's disease (AD) result in progressive cortical and subcortical atrophy. Familial autosomal dominant AD (FAD) allows us to study AD brain changes presymptomatically. METHODS: 33 subjects at risk for FAD (25 for PSEN1 and 8 for APP mutations; 22 mutation carriers and 11 controls) and 3 demented PSEN1 mutation carriers underwent T(1)-weighted MPRAGE 1.5T MRI. Using the hippocampal radial distance and cortical pattern matching techniques, we investigated the effects of carrier status and dementia diagnosis on cortical and hippocampal atrophy. All analyses were corrected for age and relative age (years to median age of disease onset in the family). RESULTS: The dementia cases had pronounced cortical atrophy in the lateral and medial parietal, posterior cingulate and frontal cortices and hippocampal atrophy bilaterally relative to both nondemented carriers and controls. Nondemented carriers did not show significant cortical thinning or hippocampal atrophy relative to controls. CONCLUSIONS: FAD is associated with thinning of the posterior association and frontal cortices and hippocampal atrophy. Larger sample sizes may be necessary to reliably identify cortical atrophy in presymptomatic carriers.
Authors: M C Chartier-Harlin; F Crawford; H Houlden; A Warren; D Hughes; L Fidani; A Goate; M Rossor; P Roques; J Hardy Journal: Nature Date: 1991-10-31 Impact factor: 49.962
Authors: N C Fox; E K Warrington; P A Freeborough; P Hartikainen; A M Kennedy; J M Stevens; M N Rossor Journal: Brain Date: 1996-12 Impact factor: 13.501
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Authors: G B Karas; P Scheltens; S A R B Rombouts; P J Visser; R A van Schijndel; N C Fox; F Barkhof Journal: Neuroimage Date: 2004-10 Impact factor: 6.556
Authors: J C Janssen; J A Beck; T A Campbell; A Dickinson; N C Fox; R J Harvey; H Houlden; M N Rossor; J Collinge Journal: Neurology Date: 2003-01-28 Impact factor: 9.910
Authors: R Sherrington; E I Rogaev; Y Liang; E A Rogaeva; G Levesque; M Ikeda; H Chi; C Lin; G Li; K Holman; T Tsuda; L Mar; J F Foncin; A C Bruni; M P Montesi; S Sorbi; I Rainero; L Pinessi; L Nee; I Chumakov; D Pollen; A Brookes; P Sanseau; R J Polinsky; W Wasco; H A Da Silva; J L Haines; M A Perkicak-Vance; R E Tanzi; A D Roses; P E Fraser; J M Rommens; P H St George-Hyslop Journal: Nature Date: 1995-06-29 Impact factor: 49.962
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Authors: Tammie L S Benzinger; Tyler Blazey; Clifford R Jack; Robert A Koeppe; Yi Su; Chengjie Xiong; Marcus E Raichle; Abraham Z Snyder; Beau M Ances; Randall J Bateman; Nigel J Cairns; Anne M Fagan; Alison Goate; Daniel S Marcus; Paul S Aisen; Jon J Christensen; Lindsay Ercole; Russ C Hornbeck; Angela M Farrar; Patricia Aldea; Mateusz S Jasielec; Christopher J Owen; Xianyun Xie; Richard Mayeux; Adam Brickman; Eric McDade; William Klunk; Chester A Mathis; John Ringman; Paul M Thompson; Bernardino Ghetti; Andrew J Saykin; Reisa A Sperling; Keith A Johnson; Stephen Salloway; Stephen Correia; Peter R Schofield; Colin L Masters; Christopher Rowe; Victor L Villemagne; Ralph Martins; Sebastien Ourselin; Martin N Rossor; Nick C Fox; David M Cash; Michael W Weiner; David M Holtzman; Virginia D Buckles; Krista Moulder; John C Morris Journal: Proc Natl Acad Sci U S A Date: 2013-11-05 Impact factor: 11.205