Literature DB >> 21952494

Carbonic anhydrase inhibitors: X-ray crystallographic studies for the binding of N-substituted benzenesulfonamides to human isoform II.

Anna Di Fiore1, Alfonso Maresca, Vincenzo Alterio, Claudiu T Supuran, Giuseppina De Simone.   

Abstract

N-substituted benzenesulfonamides, incorporating the N-amino-, N-hydroxy- and N-methoxy-moieties at the sulfonamide zinc binding group, have been investigated as CAIs by means of inhibition and structural studies, unraveling interesting aspects related to their inhibition mechanism. This journal is © The Royal Society of Chemistry 2011

Entities:  

Mesh：

Substances：

Year:  2011        PMID： 21952494     DOI： 10.1039/c1cc14575d

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  8 in total

1.  Carbonic Anhydrase Inhibition with Benzenesulfonamides and Tetrafluorobenzenesulfonamides Obtained via Click Chemistry.

Authors:  Nicolino Pala; Laura Micheletto; Mario Sechi; Mayank Aggarwal; Fabrizio Carta; Robert McKenna; Claudiu T Supuran
Journal:  ACS Med Chem Lett       Date:  2014-06-07       Impact factor: 4.345

2.  A Mononuclear, Nonheme FeII-Piloty's Acid (PhSO2NHOH) Adduct: An Intermediate in the Production of {FeNO}7/8 Complexes from Piloty's Acid.

Authors:  Alex M Confer; Avery C Vilbert; Aniruddha Dey; Kyle M Lancaster; David P Goldberg
Journal:  J Am Chem Soc       Date:  2019-04-17       Impact factor: 15.419

3.  Neutron diffraction of acetazolamide-bound human carbonic anhydrase II reveals atomic details of drug binding.

Authors:  S Zoë Fisher; Mayank Aggarwal; Andrey Y Kovalevsky; David N Silverman; Robert McKenna
Journal:  J Am Chem Soc       Date:  2012-09-04       Impact factor: 15.419

4.  Carbon- versus sulphur-based zinc binding groups for carbonic anhydrase inhibitors?

Authors:  Claudiu T Supuran
Journal:  J Enzyme Inhib Med Chem       Date:  2018-12       Impact factor: 5.051

5.  Fluoroenesulphonamides: N-sulphonylurea isosteres showing nanomolar selective cancer-related transmembrane human carbonic anhydrase inhibition.

Authors:  Benoit Métayer; Andrea Angeli; Agnès Mingot; Kévin Jouvin; Gwilherm Evano; Claudiu T Supuran; Sébastien Thibaudeau
Journal:  J Enzyme Inhib Med Chem       Date:  2018-12       Impact factor: 5.051

6.  Inhibition studies on a panel of human carbonic anhydrases with N1-substituted secondary sulfonamides incorporating thiazolinone or imidazolone-indole tails.

Authors:  Fadi M Awadallah; Silvia Bua; Walaa R Mahmoud; Hossam H Nada; Alessio Nocentini; Claudiu T Supuran
Journal:  J Enzyme Inhib Med Chem       Date:  2018-12       Impact factor: 5.051

7.  Fibrate-based N-acylsulphonamides targeting carbonic anhydrases: synthesis, biochemical evaluation, and docking studies.

Authors:  Alessandra Ammazzalorso; Simone Carradori; Andrea Angeli; Atilla Akdemir; Barbara De Filippis; Marialuigia Fantacuzzi; Letizia Giampietro; Cristina Maccallini; Rosa Amoroso; Claudiu T Supuran
Journal:  J Enzyme Inhib Med Chem       Date:  2019-12       Impact factor: 5.051

8.  Exploring benzoxaborole derivatives as carbonic anhydrase inhibitors: a structural and computational analysis reveals their conformational variability as a tool to increase enzyme selectivity.

Authors:  Emma Langella; Vincenzo Alterio; Katia D'Ambrosio; Roberta Cadoni; Jean-Yves Winum; Claudiu T Supuran; Simona Maria Monti; Giuseppina De Simone; Anna Di Fiore
Journal:  J Enzyme Inhib Med Chem       Date:  2019-12       Impact factor: 5.051
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.