Literature DB >> 21951544

Chemical screening in zebrafish for novel biological and therapeutic discovery.

Justin L Tan1, Leonard I Zon.   

Abstract

Zebrafish chemical screening allows for an in vivo assessment of small molecule modulation of biological processes. Compound toxicities, chemical alterations by metabolism, pharmacokinetic and pharmacodynamic properties, and modulation of cell niches can be studied with this method. Furthermore, zebrafish screening is straightforward and cost-effective. Zebrafish provide an invaluable platform for novel therapeutic discovery through chemical screening.
Copyright © 2011 Elsevier Inc. All rights reserved.

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Year:  2011        PMID： 21951544     DOI： 10.1016/B978-0-12-381320-6.00021-7

Source DB:  PubMed          Journal:  Methods Cell Biol        ISSN： 0091-679X            Impact factor:   1.441


  22 in total

Review 1.  Zebrafish models of human liver development and disease.

Authors:  Benjamin J Wilkins; Michael Pack
Journal:  Compr Physiol       Date:  2013-07       Impact factor: 9.090

Review 2.  Analysis of myelinated axon formation in zebrafish.

Authors:  M D'Rozario; K R Monk; S C Petersen
Journal:  Methods Cell Biol       Date:  2016-09-29       Impact factor: 1.441

3.  Hooked! Modeling human disease in zebrafish.

Authors:  Cristina Santoriello; Leonard I Zon
Journal:  J Clin Invest       Date:  2012-07-02       Impact factor: 14.808

4.  An in vivo platform for rapid high-throughput antitubercular drug discovery.

Authors:  Kevin Takaki; Christine L Cosma; Mark A Troll; Lalita Ramakrishnan
Journal:  Cell Rep       Date:  2012-07-20       Impact factor: 9.423

5.  A bone to pick with zebrafish.

Authors:  Eirinn W Mackay; Alexander Apschner; Stefan Schulte-Merker
Journal:  Bonekey Rep       Date:  2013-11-13

Review 6.  Utilization of zebrafish for intravital study of eukaryotic pathogen-host interactions.

Authors:  Remi L Gratacap; Robert T Wheeler
Journal:  Dev Comp Immunol       Date:  2014-02-01       Impact factor: 3.636

Review 7.  Interpreting human genetic variation with in vivo zebrafish assays.

Authors:  Erica E Davis; Stephan Frangakis; Nicholas Katsanis
Journal:  Biochim Biophys Acta       Date:  2014-06-02

Review 8.  Identifying Novel Cancer Therapies Using Chemical Genetics and Zebrafish.

Authors:  Michelle Dang; Rachel Fogley; Leonard I Zon
Journal:  Adv Exp Med Biol       Date:  2016       Impact factor: 2.622

9.  Anticancer Activity and In Vitro to In Vivo Mechanistic Recapitulation of Novel Ruthenium-Based Metallodrugs in the Zebrafish Model.

Authors:  Brittany F Karas; Jordan M Hotz; Brian M Gural; Kristin R Terez; Victoria L DiBona; Leonor Côrte-Real; Andreia Valente; Brian T Buckley; Keith R Cooper
Journal:  Toxicol Sci       Date:  2021-07-16       Impact factor: 4.849

10.  Of fish and men: using zebrafish to fight human diseases.

Authors:  Julien Ablain; Leonard I Zon
Journal:  Trends Cell Biol       Date:  2013-12       Impact factor: 20.808
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