BACKGROUND AND AIM: In the setting of advancing maternal age, escalating obesity and increasing Gestational Diabetes Mellitus (GDM) rates, we aimed to develop a novel risk prediction tool to identify high-risk women in early pregnancy, specifically to facilitate targeted antenatal prevention of GDM. METHODS: In this retrospective, observational study, first-trimester data collected routinely by midwifery staff in 4276 women attending a large tertiary hospital in 2007/2008 was analysed to examine predictive factors for GDM. GDM was diagnosed with a 28-week oral glucose tolerance test. The data set included a derivation group (n=2880, from 2007 deliveries) and a validation group (n = 1396, from 2008). Multivariate analysis generated a scoring system. RESULTS: GDM was significantly correlated with a number of factors: past history of GDM, increasing maternal age and body mass index, Asian descent and family history of diabetes. Validation group clinical scores achieved a sensitivity of 61.3% and specificity of 71.4% for differentiating women according to their risk of developing GDM. CONCLUSIONS: Risk factors for GDM are easily identified at the first-trimester midwifery hospital booking visit. A risk prediction tool, derived from risk factors in early pregnancy, identifies women at high risk of GDM. This represents a novel approach to facilitate targeted early intervention with the potential to prevent development of, or ameliorate, GDM.
BACKGROUND AND AIM: In the setting of advancing maternal age, escalating obesity and increasing Gestational Diabetes Mellitus (GDM) rates, we aimed to develop a novel risk prediction tool to identify high-risk women in early pregnancy, specifically to facilitate targeted antenatal prevention of GDM. METHODS: In this retrospective, observational study, first-trimester data collected routinely by midwifery staff in 4276 women attending a large tertiary hospital in 2007/2008 was analysed to examine predictive factors for GDM. GDM was diagnosed with a 28-week oral glucose tolerance test. The data set included a derivation group (n=2880, from 2007 deliveries) and a validation group (n = 1396, from 2008). Multivariate analysis generated a scoring system. RESULTS: GDM was significantly correlated with a number of factors: past history of GDM, increasing maternal age and body mass index, Asian descent and family history of diabetes. Validation group clinical scores achieved a sensitivity of 61.3% and specificity of 71.4% for differentiating women according to their risk of developing GDM. CONCLUSIONS: Risk factors for GDM are easily identified at the first-trimester midwifery hospital booking visit. A risk prediction tool, derived from risk factors in early pregnancy, identifies women at high risk of GDM. This represents a novel approach to facilitate targeted early intervention with the potential to prevent development of, or ameliorate, GDM.
Authors: Katrien Benhalima; Paul Van Crombrugge; Carolien Moyson; Johan Verhaeghe; Sofie Vandeginste; Hilde Verlaenen; Chris Vercammen; Toon Maes; Els Dufraimont; Christophe De Block; Yves Jacquemyn; Farah Mekahli; Katrien De Clippel; Annick Van Den Bruel; Anne Loccufier; Annouschka Laenen; Caro Minschart; Roland Devlieger; Chantal Mathieu Journal: Acta Diabetol Date: 2020-01-08 Impact factor: 4.280
Authors: Ana M Ramos-Leví; Natalia Pérez-Ferre; M Dolores Fernández; Laura Del Valle; Elena Bordiu; Ana Rosa Bedia; Miguel A Herraiz; M José Torrejón; Alfonso L Calle-Pascual Journal: Int J Endocrinol Date: 2012-04-12 Impact factor: 3.257
Authors: Grammata Kotzaeridi; Julia Blätter; Daniel Eppel; Ingo Rosicky; Martina Mittlböck; Gülen Yerlikaya-Schatten; Christian Schatten; Peter Husslein; Wolfgang Eppel; Evelyn A Huhn; Andrea Tura; Christian S Göbl Journal: Eur J Clin Invest Date: 2021-06-18 Impact factor: 5.722
Authors: Polina V Popova; Alexandra A Klyushina; Lyudmila B Vasilyeva; Alexandra S Tkachuk; Yana A Bolotko; Andrey S Gerasimov; Evgenii A Pustozerov; Ekaterina N Kravchuk; Alexander Predeus; Anna A Kostareva; Elena N Grineva Journal: Oncotarget Date: 2017-12-06