OBJECTIVE: Schizophrenia has been associated with age-related abnormalities, including abnormal glucose tolerance, increased pulse pressure, increased inflammation, abnormal stem cell signaling, and shorter telomere length. These metabolic abnormalities and other findings suggest that schizophrenia and related disorders might be associated with accelerated aging. Testosterone activity has a progressive decline with increasing age. METHODS: We tested the hypothesis that circulating biologically active testosterone is lower in newly diagnosed, antipsychotic-naive male patients with nonaffective psychosis than in matched control subjects. RESULTS: Patients (n = 33) were matched to control subjects (n = 33) for age, sex, body mass index, socioeconomic status of the family of origin, and smoking. The free androgen index, a measure of biologically active testosterone, was significantly lower in the psychosis group (mean [standard deviation] = 57.7% [26.1]) than in control subjects (71.6% [27.0], p = .04), with an effect size of 0.53. Multivariate analysis also supported the findings. In the psychosis group, free androgen index had a significant negative correlation with the conceptual disorganization item (r = -0.35, p = .049) but not with reality distortion (r = -0.21, p = .24), negative symptoms (r = 0.004, p = .98), or depression (r = -0.014, p = .94). CONCLUSIONS: Lower testosterone level is consistent with accelerated aging in nonaffective psychosis, but further testing of this hypothesis is needed.
OBJECTIVE:Schizophrenia has been associated with age-related abnormalities, including abnormal glucose tolerance, increased pulse pressure, increased inflammation, abnormal stem cell signaling, and shorter telomere length. These metabolic abnormalities and other findings suggest that schizophrenia and related disorders might be associated with accelerated aging. Testosterone activity has a progressive decline with increasing age. METHODS: We tested the hypothesis that circulating biologically active testosterone is lower in newly diagnosed, antipsychotic-naive male patients with nonaffective psychosis than in matched control subjects. RESULTS:Patients (n = 33) were matched to control subjects (n = 33) for age, sex, body mass index, socioeconomic status of the family of origin, and smoking. The free androgen index, a measure of biologically active testosterone, was significantly lower in the psychosis group (mean [standard deviation] = 57.7% [26.1]) than in control subjects (71.6% [27.0], p = .04), with an effect size of 0.53. Multivariate analysis also supported the findings. In the psychosis group, free androgen index had a significant negative correlation with the conceptual disorganization item (r = -0.35, p = .049) but not with reality distortion (r = -0.21, p = .24), negative symptoms (r = 0.004, p = .98), or depression (r = -0.014, p = .94). CONCLUSIONS: Lower testosterone level is consistent with accelerated aging in nonaffective psychosis, but further testing of this hypothesis is needed.
Authors: Hanan D Trotman; Carrie W Holtzman; Arthur T Ryan; Daniel I Shapiro; Allison N MacDonald; Sandra M Goulding; Joy L Brasfield; Elaine F Walker Journal: Horm Behav Date: 2013-07 Impact factor: 3.587
Authors: Peter Kochunov; David C Glahn; Laura M Rowland; Rene L Olvera; Anderson Winkler; Yi-Hong Yang; Hemalatha Sampath; Will T Carpenter; Ravindranath Duggirala; Joanne Curran; John Blangero; L Elliot Hong Journal: Biol Psychiatry Date: 2012-11-28 Impact factor: 13.382
Authors: Stacy S Drury; Elizabeth A Shirtcliff; Andrew Shachet; Jenny Phan; Emily Mabile; Zoë H Brett; Michael Wren; Kyle Esteves; Katherine P Theall Journal: Am J Med Sci Date: 2014-08 Impact factor: 2.378
Authors: Ans Vercammen; Ashley J Skilleter; Rhoshel Lenroot; Stanley V Catts; Cynthia Shannon Weickert; Thomas W Weickert Journal: PLoS One Date: 2013-10-31 Impact factor: 3.240
Authors: Alex T Raben; Victoria S Marshe; Araba Chintoh; Ilona Gorbovskaya; Daniel J Müller; Margaret K Hahn Journal: Front Neurosci Date: 2018-01-22 Impact factor: 4.677