J W Huh1, Y Y Jeong, H R Kim, Y J Kim. 1. Department of Surgery, Chonnam National University Hwasun Hospital and Medical School, Gwangju, Korea.
Abstract
PURPOSE: This study evaluated the prognostic value of preoperative locoregional staging in patients with colon cancer and who underwent curative resection. METHODS: A total of 536 consecutive patients who underwent curative resection for colon cancer from February 1999 to November 2007 were prospectively enrolled. The clinicopathological variables, including the radiological staging using computed tomography, were analyzed for the prognostic significance. RESULTS: The 5-year overall survival rates of the patients with radiological T1, T2, T3, and T4 were 96%, 89%, 75%, and 79%, respectively (P = 0.028). The 5-year overall survival rates were 83%, 76%, and 54%, respectively, for patients with radiological N0, N1, and N2 disease (P < 0.001). The 5-year overall survival rates of the patients with radiological TNM (tumor-node-metastasis) stages I, II, and III were 90%, 81%, and 70%, respectively (P < 0.001) and the 5-year overall survival rates of the patients with pathological TNM stages I, II, and III were 93%, 80%, and 70%, respectively (P = 0.001). On multivariate analysis, the radiological T and N categories remained independent prognostic factors for both overall survival and disease-free survival. CONCLUSION: Radiological staging is an independent predictor of long-term survival in the preoperative setting.
PURPOSE: This study evaluated the prognostic value of preoperative locoregional staging in patients with colon cancer and who underwent curative resection. METHODS: A total of 536 consecutive patients who underwent curative resection for colon cancer from February 1999 to November 2007 were prospectively enrolled. The clinicopathological variables, including the radiological staging using computed tomography, were analyzed for the prognostic significance. RESULTS: The 5-year overall survival rates of the patients with radiological T1, T2, T3, and T4 were 96%, 89%, 75%, and 79%, respectively (P = 0.028). The 5-year overall survival rates were 83%, 76%, and 54%, respectively, for patients with radiological N0, N1, and N2 disease (P < 0.001). The 5-year overall survival rates of the patients with radiological TNM (tumor-node-metastasis) stages I, II, and III were 90%, 81%, and 70%, respectively (P < 0.001) and the 5-year overall survival rates of the patients with pathological TNM stages I, II, and III were 93%, 80%, and 70%, respectively (P = 0.001). On multivariate analysis, the radiological T and N categories remained independent prognostic factors for both overall survival and disease-free survival. CONCLUSION: Radiological staging is an independent predictor of long-term survival in the preoperative setting.
Authors: Audrey H Choi; Rebecca A Nelson; Hans F Schoellhammer; Won Cho; Michelle Ko; Amanda Arrington; Christopher R Oxner; Marwan Fakih; Jimmie Wong; Stephen M Sentovich; Julio Garcia-Aguilar; Joseph Kim Journal: World J Gastrointest Surg Date: 2015-07-27
Authors: O Jannasch; A Udelnow; G Romano; A Dziki; D Pavalkis; H Lippert; P Mroczkowski Journal: Langenbecks Arch Surg Date: 2014-02-28 Impact factor: 3.445
Authors: M L Malmstrøm; S Brisling; T W Klausen; A Săftoiu; T Perner; P Vilmann; I Gögenur Journal: Int J Colorectal Dis Date: 2017-11-07 Impact factor: 2.571
Authors: J Arredondo; E Pastor; V Simó; M Beltrán; C Castañón; M C Magdaleno; I Matanza; M Notarnicola; B Ielpo Journal: Tech Coloproctol Date: 2020-07-14 Impact factor: 3.781
Authors: Bodil Elisabeth Engelmann; Annika Loft; Andreas Kjær; Hans Jørgen Nielsen; Anne Kiil Berthelsen; Tina Binderup; Kim Brinch; Nils Brünner; Thomas Alexander Gerds; Gunilla Høyer-Hansen; Michael Holmsgaard Kristensen; Engin Yeter Kurt; Jan Erik Latocha; Gunnar Lindblom; Carsten Sloth; Liselotte Højgaard Journal: Scand J Gastroenterol Date: 2013-11-29 Impact factor: 2.423