Literature DB >> 21948222

Rise of herbal and traditional medicine in erectile dysfunction management.

Christopher C K Ho1, Hui Meng Tan.   

Abstract

Herbal medicine long has been used in the management of sexual dysfunction, including erectile dysfunction. Many patients have attested to the efficacy of this treatment. However, is it evidence-based medicine? Studies have been done on animal models, mainly in the laboratory. However, randomized controlled trials on humans are scarce. The only herbal medications that have been studied for erectile dysfunction are Panax ginseng, Butea superba, Epimedium herbs (icariin), Tribulus terrestris, Securidaca longipedunculata, Piper guineense, and yohimbine. Of these, only Panax ginseng, B. superb, and yohimbine have published studies done on humans. Unfortunately, these published trials on humans were not robust. Many herbal therapies appear to have potential benefits, and similarly, the health risks of various phytotherapeutic compounds need to be elucidated. Properly designed human trials should be worked out and encouraged to determine the efficacy and safety of potential phytotherapies.

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Year:  2011        PMID: 21948222     DOI: 10.1007/s11934-011-0217-x

Source DB:  PubMed          Journal:  Curr Urol Rep        ISSN: 1527-2737            Impact factor:   3.092


  58 in total

1.  Effect of Lepidium meyenii (Maca) on spermatogenesis in male rats acutely exposed to high altitude (4340 m).

Authors:  G F Gonzales; M Gasco; A Córdova; A Chung; J Rubio; L Villegas
Journal:  J Endocrinol       Date:  2004-01       Impact factor: 4.286

2.  Effect of Lepidium meyenii (MACA) on sexual desire and its absent relationship with serum testosterone levels in adult healthy men.

Authors:  G F Gonzales; A Córdova; K Vega; A Chung; A Villena; C Góñez; S Castillo
Journal:  Andrologia       Date:  2002-12       Impact factor: 2.775

Review 3.  Constituents and pharmacological effects of Eucommia and Siberian ginseng.

Authors:  T Deyama; S Nishibe; Y Nakazawa
Journal:  Acta Pharmacol Sin       Date:  2001-12       Impact factor: 6.150

4.  Prejunctional alpha 2-adrenoceptors inhibit nitrergic neurotransmission in horse penile resistance arteries.

Authors:  U Simonsen; D Prieto; M Hernández; I Sáenz de Tejada; A García-Sacristán
Journal:  J Urol       Date:  1997-06       Impact factor: 7.450

5.  Extraction of bioactive principles from Mucuna pruriens seeds.

Authors:  Laxminarain Misra; Hildebert Wagner
Journal:  Indian J Biochem Biophys       Date:  2007-02       Impact factor: 1.918

6.  Butea superba Roxb. enhances penile erection in rats.

Authors:  Chainarong Tocharus; Yuthana Smitasiri; Rattima Jeenapongsa
Journal:  Phytother Res       Date:  2006-06       Impact factor: 5.878

7.  The use of Butea superba (Roxb.) compared to sildenafil for treating erectile dysfunction.

Authors:  Jeff R Cortés-González; Jorge A Arratia-Maqueo; Lauro S Gómez-Guerra; Anders R Holmberg
Journal:  BJU Int       Date:  2009-07-14       Impact factor: 5.588

8.  Efficacy and safety of a novel combination of L-arginine glutamate and yohimbine hydrochloride: a new oral therapy for erectile dysfunction.

Authors:  Thierry Lebret; Jean-Marie Hervé; Philippe Gorny; Manuel Worcel; Henry Botto
Journal:  Eur Urol       Date:  2002-06       Impact factor: 20.096

9.  Subjective effects of Lepidium meyenii (Maca) extract on well-being and sexual performances in patients with mild erectile dysfunction: a randomised, double-blind clinical trial.

Authors:  T Zenico; A F G Cicero; L Valmorri; M Mercuriali; E Bercovich
Journal:  Andrologia       Date:  2009-04       Impact factor: 2.775

10.  Effect of Epimedium brevicornum Maxim extract on elicitation of penile erection in the rat.

Authors:  Kuang-Kuo Chen; Jen-Hwey Chiu
Journal:  Urology       Date:  2006-03       Impact factor: 2.649

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  10 in total

1.  Yohimbine Directly Induces Cardiotoxicity on Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes.

Authors:  Yiqi Gong; Li Yang; Jun Tang; Jijian Zheng; Nevin Witman; Philipp Jakob; Yao Tan; Minglu Liu; Ying Chen; Huijing Wang; Wei Fu; Wei Wang
Journal:  Cardiovasc Toxicol       Date:  2021-11-24       Impact factor: 3.231

2.  Red ginseng polysaccharide exhibits anticancer activity through GPX4 downregulation-induced ferroptosis.

Authors:  Feng-Guo Zhai; Qi-Chao Liang; Yi-Yan Wu; Jia-Qi Liu; Jia-Wei Liu
Journal:  Pharm Biol       Date:  2022-12       Impact factor: 3.889

Review 3.  Effect of Herbal Medicine on Fertility Potential in Experimental Animals - an Update Review.

Authors:  Bassam A Alahmadi
Journal:  Mater Sociomed       Date:  2020-06

4.  Randomized, Triple-Blinded, Placebo-Controlled Trial of SA3X (Spilanthes acmella) for the Management of Erectile Dysfunction.

Authors:  Nabnita Patnaik; Kumar Guru Mishra; Nihar Ranjan Pradhan
Journal:  Cureus       Date:  2022-04-09

5.  Effects of Korean ginseng berry extract (GB0710) on penile erection: evidence from in vitro and in vivo studies.

Authors:  K S Cho; C W Park; C K Kim; H Y Jeon; W G Kim; S J Lee; Y M Kim; J Y Lee; Y D Choi
Journal:  Asian J Androl       Date:  2013-05-27       Impact factor: 3.285

6.  In vitro and in vivo evaluation of tissue-cultured mountain ginseng on penile erection.

Authors:  Ho Sung Lee; Young Joo Lee; Yoon Hee Chung; Moo Yeol Lee; Sung Tae Kim; Sung Kwon Ko; Mariko Momoi; Yutaka Kondoh; Fumio Sasaki; Ji Hoon Jeong
Journal:  J Ginseng Res       Date:  2015-11-02       Impact factor: 6.060

7.  Ginseng for erectile dysfunction.

Authors:  Hye Won Lee; Myeong Soo Lee; Tae-Hun Kim; Terje Alraek; Chris Zaslawski; Jong Wook Kim; Du Geon Moon
Journal:  Cochrane Database Syst Rev       Date:  2021-04-19

8.  Assessment of protective and anti-oxidant properties of Tribulus terrestris fruits against testicular toxicity in rats.

Authors:  Mostafa Abbas Shalaby; Ashraf Abd El-Khalik Hammouda
Journal:  J Intercult Ethnopharmacol       Date:  2014-07-07

9.  Icariin ameliorates neuropathological changes, TGF-β1 accumulation and behavioral deficits in a mouse model of cerebral amyloidosis.

Authors:  Zhi-Yuan Zhang; Chaoyun Li; Caroline Zug; Hermann J Schluesener
Journal:  PLoS One       Date:  2014-08-07       Impact factor: 3.240

10.  Ethnobotanical Study of Plants Used in the Management of HIV/AIDS-Related Diseases in Livingstone, Southern Province, Zambia.

Authors:  Kazhila C Chinsembu
Journal:  Evid Based Complement Alternat Med       Date:  2016-03-16       Impact factor: 2.629

  10 in total

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