Literature DB >> 21947483

Obesity-related juvenile form of cartilage lesions: a new affliction in the knees of morbidly obese children and adolescents.

Harald K Widhalm1, Stefan Marlovits, Goetz H Welsch, Albert Dirisamer, Andreas Neuhold, Martijn van Griensven, Rudolf Seemann, Vilmos Vécsei, Kurt Widhalm.   

Abstract

OBJECTIVES: Overweight and obesity are afflictions that lead to an increased risk of health problems including joint problems. The aim of the study was to assess the condition of articular cartilage in obese adolescent patients suffering from knee pain.
METHODS: MRI of 24 knees of 20 morbidly obese patients, mean age 14.2 years, was performed in an open 1.0 Tesla MR system, where the cartilage, the quality and structure of the menisci, and the presence or absence of surrounding changes was examined.
RESULTS: In all patients a cartilage lesion in at least one region of the knee could be detected. Retropatellar cartilage lesions have been found in 19 knees. Ten cartilage lesions grade I, and four lesions grade II have been described in the lateral compartment of the knee, whereas the medial compartment showed in eight cases a grade I, in 13 cases a grade II and in two cases a grade III cartilage lesion. Meniscal changes were assessed in most patients.
CONCLUSION: Morbidly obese children and adolescents show major abnormalities in the articular cartilage of the knee. Whether obesity alone is the causal factor for the development of the pattern of these changes, remains to be seen. KEY POINTS: • Morbidly obese children and adolescents often suffer from knee pain • Prospective study showed cartilage and meniscal lesions in morbidly obese adolescents • MRI is an adequate tool for assessing cartilage lesions even in morbidly obese patients • It is unclear whether cartilage abnormalities are mainly due to mechanical overload.

Entities:  

Mesh:

Year:  2011        PMID: 21947483     DOI: 10.1007/s00330-011-2281-5

Source DB:  PubMed          Journal:  Eur Radiol        ISSN: 0938-7994            Impact factor:   5.315


  46 in total

Review 1.  Overweight children and adolescents: description, epidemiology, and demographics.

Authors:  R P Troiano; K M Flegal
Journal:  Pediatrics       Date:  1998-03       Impact factor: 7.124

2.  A proinflammatory state is detectable in obese children and is accompanied by functional and morphological vascular changes.

Authors:  Stylianos Kapiotis; Gregor Holzer; Georg Schaller; Markus Haumer; Harald Widhalm; Daniel Weghuber; Bernd Jilma; Georg Röggla; Michael Wolzt; Kurt Widhalm; Oswald F Wagner
Journal:  Arterioscler Thromb Vasc Biol       Date:  2006-09-14       Impact factor: 8.311

3.  Knee effusions, popliteal cysts, and synovial thickening: association with knee pain in osteoarthritis.

Authors:  C L Hill; D G Gale; C E Chaisson; K Skinner; L Kazis; M E Gale; D T Felson
Journal:  J Rheumatol       Date:  2001-06       Impact factor: 4.666

4.  Meniscal tears: pathologic correlation with MR imaging.

Authors:  D W Stoller; C Martin; J V Crues; L Kaplan; J H Mink
Journal:  Radiology       Date:  1987-06       Impact factor: 11.105

5.  Ultrasound evaluation of popliteal cysts on osteoarthritis of the knee.

Authors:  A G Fam; S R Wilson; S Holmberg
Journal:  J Rheumatol       Date:  1982 May-Jun       Impact factor: 4.666

6.  Prevalence of overweight and obesity in the United States, 1999-2004.

Authors:  Cynthia L Ogden; Margaret D Carroll; Lester R Curtin; Margaret A McDowell; Carolyn J Tabak; Katherine M Flegal
Journal:  JAMA       Date:  2006-04-05       Impact factor: 56.272

7.  MR imaging findings in the follow-up of patients with different stages of knee osteoarthritis and the correlation with clinical symptoms.

Authors:  Catherine M Phan; Thomas M Link; Gabrielle Blumenkrantz; Timothy C Dunn; Michael D Ries; Lynne S Steinbach; Sharmila Majumdar
Journal:  Eur Radiol       Date:  2005-10-13       Impact factor: 5.315

8.  Cartilage defects are associated with physical disability in obese adults.

Authors:  Ananthila Anandacoomarasamy; Garett Smith; Steven Leibman; Ian Caterson; Bruno Giuffre; Marlene Fransen; Philip Sambrook; Lyn March
Journal:  Rheumatology (Oxford)       Date:  2009-08-18       Impact factor: 7.580

Review 9.  Obesity in children and young people: a crisis in public health.

Authors:  T Lobstein; L Baur; R Uauy
Journal:  Obes Rev       Date:  2004-05       Impact factor: 9.213

10.  Prevalence and trends in overweight among US children and adolescents, 1999-2000.

Authors:  Cynthia L Ogden; Katherine M Flegal; Margaret D Carroll; Clifford L Johnson
Journal:  JAMA       Date:  2002-10-09       Impact factor: 56.272

View more
  9 in total

1.  Osteoarthritis in morbidly obese children and adolescents, an age-matched controlled study.

Authors:  H K Widhalm; R Seemann; M Hamboeck; M Mittlboeck; A Neuhold; K Friedrich; S Hajdu; K Widhalm
Journal:  Knee Surg Sports Traumatol Arthrosc       Date:  2014-05-20       Impact factor: 4.342

2.  Serum soluble urokinase plasminogen activator receptor in adolescents: interaction of chronic pain and obesity.

Authors:  Hershel Raff; Jonathan M Phillips; Pippa M Simpson; Steven J Weisman; Keri R Hainsworth
Journal:  Pain Rep       Date:  2020-07-22

3.  Circulating inflammatory biomarkers in adolescents: evidence of interactions between chronic pain and obesity.

Authors:  Keri R Hainsworth; Pippa M Simpson; Hershel Raff; Mitchell H Grayson; Liyun Zhang; Steven J Weisman
Journal:  Pain Rep       Date:  2021-04-01

Review 4.  Articular Cartilage Repair of the Knee in Children and Adolescents.

Authors:  Gian M Salzmann; Philipp Niemeyer; Alfred Hochrein; Martin J Stoddart; Peter Angele
Journal:  Orthop J Sports Med       Date:  2018-03-13

5.  Timely diagnosis of malalignment of the distal extremities is crucial in morbidly obese juveniles.

Authors:  Franz Landauer; Gerda Huber; Katharina Paulmichl; Grace O'Malley; Harald Mangge; Daniel Weghuber
Journal:  Obes Facts       Date:  2013-12-06       Impact factor: 3.942

Review 6.  Gait Pattern, Impact to the Skeleton and Postural Balance in Overweight and Obese Children: A Review.

Authors:  Nili Steinberg; Dan Nemet; Michal Pantanowitz; Alon Eliakim
Journal:  Sports (Basel)       Date:  2018-07-31

7.  A Pilot Study of Iyengar Yoga for Pediatric Obesity: Effects on Gait and Emotional Functioning.

Authors:  Keri R Hainsworth; Xue Cheng Liu; Pippa M Simpson; Ann M Swartz; Nina Linneman; Susan T Tran; Gustavo R Medrano; Bryant Mascarenhas; Liyun Zhang; Steven J Weisman
Journal:  Children (Basel)       Date:  2018-07-04

8.  Early Efficacy of Intra-Articular HYADD® 4 (Hymovis®) Injections for Symptomatic Knee Osteoarthritis.

Authors:  Ferdinando Priano
Journal:  Joints       Date:  2017-07-28

9.  Microarray analysis of the molecular mechanisms associated with age and body mass index in human meniscal injury.

Authors:  Peiyan Huang; Jun Gu; Junguo Wu; Lei Geng; Yang Hong; Siqun Wang; Minghai Wang
Journal:  Mol Med Rep       Date:  2018-11-21       Impact factor: 2.952

  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.