Literature DB >> 21947084

The role of lipoprotein receptors on the physiological function of APP.

Timo Wagner1, Claus U Pietrzik.   

Abstract

In this review, we will primarily focus on the role of members of the low-density lipoprotein receptor (LDL-R) family that are involved in trafficking and processing of the amyloid precursor protein (APP). We will discuss the role of the LDL-receptor family members, low-density lipoprotein receptor-related protein 1 (LRP1), LRP1b, apolipoprotein E receptor 2, sortilin-related receptor (SorLA/LR11) and megalin/LRP2 on the physiological function of APP and its cellular localization. Additionally, we will focus on adaptor proteins that have been shown to influence the physiological function of LDL-R family members in combination with APP processing. The results in this review emphasize that the physiological function of APP cannot be explained by the focus on the APP protein alone but rather in combination with various direct or indirect interaction partners within the cellular environment.

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Year:  2011        PMID： 21947084     DOI： 10.1007/s00221-011-2876-8

Source DB:  PubMed          Journal:  Exp Brain Res        ISSN： 0014-4819            Impact factor:   1.972


  94 in total

1.  Apolipoprotein E receptor 2 is involved in neuritic plaque formation in APP sw mice.

Authors:  Yumiko Motoi; Masako Itaya; Hideo Mori; Yoshikuni Mizuno; Tadao Iwasaki; Hiroaki Hattori; Seichi Haga; Kazuhiko Ikeda
Journal:  Neurosci Lett       Date:  2004-09-23       Impact factor: 3.046

2.  Amyloid precursor-like protein 1 influences endocytosis and proteolytic processing of the amyloid precursor protein.

Authors:  Stephanie Neumann; Susanne Schöbel; Sebastian Jäger; Anna Trautwein; Christian Haass; Claus U Pietrzik; Stefan F Lichtenthaler
Journal:  J Biol Chem       Date:  2005-12-12       Impact factor: 5.157

3.  Protein interactions among Fe65, the low-density lipoprotein receptor-related protein, and the amyloid precursor protein.

Authors:  Melinda M Mulvihill; Miklos Guttman; Elizabeth A Komives
Journal:  Biochemistry       Date:  2011-06-24       Impact factor: 3.162

4.  Activation and functional characterization of the mosaic receptor SorLA/LR11.

Authors:  L Jacobsen; P Madsen; C Jacobsen; M S Nielsen; J Gliemann; C M Petersen
Journal:  J Biol Chem       Date:  2001-04-09       Impact factor: 5.157

5.  Enhanced amyloidogenic metabolism of the amyloid beta-protein precursor in the X11L-deficient mouse brain.

Authors:  Yoshitake Sano; Aiko Syuzo-Takabatake; Tadashi Nakaya; Yuhki Saito; Susumu Tomita; Shigeyoshi Itohara; Toshiharu Suzuki
Journal:  J Biol Chem       Date:  2006-10-10       Impact factor: 5.157

6.  Interaction of reelin with amyloid precursor protein promotes neurite outgrowth.

Authors:  Hyang-Sook Hoe; Kea Joo Lee; Rosalind S E Carney; Jiyeon Lee; Alexandra Markova; Ji-Yun Lee; Brian W Howell; Bradley T Hyman; Daniel T S Pak; Guojun Bu; G William Rebeck
Journal:  J Neurosci       Date:  2009-06-10       Impact factor: 6.167

7.  Loss of LR11/SORLA enhances early pathology in a mouse model of amyloidosis: evidence for a proximal role in Alzheimer's disease.

Authors:  Sara E Dodson; Olav M Andersen; Vinit Karmali; Jason J Fritz; Dongmei Cheng; Junmin Peng; Allan I Levey; Thomas E Willnow; James J Lah
Journal:  J Neurosci       Date:  2008-11-26       Impact factor: 6.167

8.  The low density lipoprotein receptor-related protein 1B retains beta-amyloid precursor protein at the cell surface and reduces amyloid-beta peptide production.

Authors:  Judy A Cam; Celina V Zerbinatti; Jane M Knisely; Silva Hecimovic; Yonghe Li; Guojun Bu
Journal:  J Biol Chem       Date:  2004-05-04       Impact factor: 5.157

9.  LRP1 modulates APP trafficking along early compartments of the secretory pathway.

Authors:  Elaine Waldron; Catherine Heilig; Andrea Schweitzer; Nirupa Nadella; Sebastian Jaeger; Anne M Martin; Sascha Weggen; Klaudia Brix; Claus U Pietrzik
Journal:  Neurobiol Dis       Date:  2008-05-03       Impact factor: 5.996

10.  Dissection of amyloid-beta precursor protein-dependent transcriptional transactivation.

Authors:  Xinwei Cao; Thomas C Südhof
Journal:  J Biol Chem       Date:  2004-03-24       Impact factor: 5.157
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  12 in total

1.  The physiological functions of the β-amyloid precursor protein APP.

Authors:  Ulrike C Müller; Claus U Pietrzik; Thomas Deller
Journal:  Exp Brain Res       Date:  2012-04       Impact factor: 1.972

2.  Dimerization leads to changes in APP (amyloid precursor protein) trafficking mediated by LRP1 and SorLA.

Authors:  Simone Eggert; A C Gonzalez; C Thomas; S Schilling; S M Schwarz; C Tischer; V Adam; P Strecker; V Schmidt; T E Willnow; G Hermey; C U Pietrzik; E H Koo; Stefan Kins
Journal:  Cell Mol Life Sci       Date:  2017-08-10       Impact factor: 9.261

Review 3.  Trafficking in Alzheimer's Disease: Modulation of APP Transport and Processing by the Transmembrane Proteins LRP1, SorLA, SorCS1c, Sortilin, and Calsyntenin.

Authors:  Simone Eggert; Carolin Thomas; Stefan Kins; Guido Hermey
Journal:  Mol Neurobiol       Date:  2017-10-27       Impact factor: 5.590

4.  LDLR-related protein 10 (LRP10) regulates amyloid precursor protein (APP) trafficking and processing: evidence for a role in Alzheimer's disease.

Authors:  Julie Brodeur; Caroline Thériault; Mélissa Lessard-Beaudoin; Alexandre Marcil; Sophie Dahan; Christine Lavoie
Journal:  Mol Neurodegener       Date:  2012-06-26       Impact factor: 14.195

5.  The Membrane-Bound Aspartyl Protease BACE1: Molecular and Functional Properties in Alzheimer's Disease and Beyond.

Authors:  Bastian Dislich; Stefan F Lichtenthaler
Journal:  Front Physiol       Date:  2012-02-17       Impact factor: 4.566

6.  Neurodegeneration in Alzheimer disease: role of amyloid precursor protein and presenilin 1 intracellular signaling.

Authors:  Mario Nizzari; Stefano Thellung; Alessandro Corsaro; Valentina Villa; Aldo Pagano; Carola Porcile; Claudio Russo; Tullio Florio
Journal:  J Toxicol       Date:  2012-02-08

7.  LRP1 Downregulates the Alzheimer's β-Secretase BACE1 by Modulating Its Intraneuronal Trafficking

Authors:  Daisuke Tanokashira; Kazumi Motoki; Seiji Minegishi; Ai Hosaka; Naomi Mamada; Akira Tamaoka; Takashi Okada; Madepalli K Lakshmana; Wataru Araki
Journal:  eNeuro       Date:  2015-04-22

8.  Phosphorylation of FE65 Ser610 by serum- and glucocorticoid-induced kinase 1 modulates Alzheimer's disease amyloid precursor protein processing.

Authors:  Wan Ning Vanessa Chow; Jacky Chi Ki Ngo; Wen Li; Yu Wai Chen; Ka Ming Vincent Tam; Ho Yin Edwin Chan; Christopher C J Miller; Kwok-Fai Lau
Journal:  Biochem J       Date:  2015-07-17       Impact factor: 3.857

9.  Transcriptomic analysis unveils correlations between regulative apoptotic caspases and genes of cholesterol homeostasis in human brain.

Authors:  Raffaella Picco; Andrea Tomasella; Federico Fogolari; Claudio Brancolini
Journal:  PLoS One       Date:  2014-10-16       Impact factor: 3.240

10.  Topologically Diverse Human Membrane Proteins Partition to Liquid-Disordered Domains in Phase-Separated Lipid Vesicles.

Authors:  Jonathan P Schlebach; Paul J Barrett; Charles A Day; Ji Hun Kim; Anne K Kenworthy; Charles R Sanders
Journal:  Biochemistry       Date:  2016-02-11       Impact factor: 3.162
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