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Literature DB >> 21946521

Taccalonolides: a microtubule stabilizer poses a new puzzle with old pieces.

Dan L Sackett¹, Tito Fojo.

Abstract

Entities: Chemical

Mesh：

Substances：

Year: 2011 PMID： 21946521 PMCID： PMC3918239 DOI： 10.4161/cc.10.19.17126

Source DB: PubMed Journal: Cell Cycle ISSN： 1551-4005 Impact factor: 4.534

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6 in total

1. A steroid derivative with paclitaxel-like effects on tubulin polymerization.

Authors: P Verdier-Pinard; Z Wang; A K Mohanakrishnan; M Cushman; E Hamel
Journal: Mol Pharmacol Date: 2000-03 Impact factor: 4.436

Review 2. Mitosis is not a key target of microtubule agents in patient tumors.

Authors: Edina Komlodi-Pasztor; Dan Sackett; Julia Wilkerson; Tito Fojo
Journal: Nat Rev Clin Oncol Date: 2011-02-01 Impact factor: 66.675

3. Sustained intracellular retention of dolastatin 10 causes its potent antimitotic activity.

Authors: P Verdier-Pinard; J A Kepler; G R Pettit; E Hamel
Journal: Mol Pharmacol Date: 2000-01 Impact factor: 4.436

4. Microtubule interactions with chemically diverse stabilizing agents: thermodynamics of binding to the paclitaxel site predicts cytotoxicity.

Authors: Rubén M Buey; Isabel Barasoain; Evelyn Jackson; Arndt Meyer; Paraskevi Giannakakou; Ian Paterson; Susan Mooberry; José M Andreu; J Fernando Díaz
Journal: Chem Biol Date: 2005-12

5. Cellular studies reveal mechanistic differences between taccalonolide A and paclitaxel.

Authors: April L Risinger; Susan L Mooberry
Journal: Cell Cycle Date: 2011-07-01 Impact factor: 4.534

6. Dolastatin 15 binds in the vinca domain of tubulin as demonstrated by Hummel-Dreyer chromatography.

Authors: Zobeida Cruz-Monserrate; Jeffrey T Mullaney; Patrick G Harran; George R Pettit; Ernest Hamel
Journal: Eur J Biochem Date: 2003-09

6 in total

4 in total

Taccalonolides: a microtubule stabilizer poses a new puzzle with old pieces.

1. A steroid derivative with paclitaxel-like effects on tubulin polymerization.

Review 2. Mitosis is not a key target of microtubule agents in patient tumors.

3. Sustained intracellular retention of dolastatin 10 causes its potent antimitotic activity.

4. Microtubule interactions with chemically diverse stabilizing agents: thermodynamics of binding to the paclitaxel site predicts cytotoxicity.

5. Cellular studies reveal mechanistic differences between taccalonolide A and paclitaxel.

6. Dolastatin 15 binds in the vinca domain of tubulin as demonstrated by Hummel-Dreyer chromatography.

1. Taccalonolide Microtubule Stabilizers.

Review 2. Taccalonolide microtubule stabilizers.

Review 3. Harnessing Plant Biodiversity for the Discovery of Novel Anticancer Drugs Targeting Microtubules.

4. The taccalonolides and paclitaxel cause distinct effects on microtubule dynamics and aster formation.