Literature DB >> 21946307

The role of neurotensin in passive avoidance learning in the rat central nucleus of amygdala.

Kristóf László1, Krisztián Tóth, Erika Kertes, László Péczely, Tamás Ollmann, Anna Madarassy-Szücs, László Lénárd.   

Abstract

Tridecapeptide neurotensin (NT) acts as a neurotransmitter and/or neuromodulator and plays a role in learning and reinforcement. The central nucleus of amygdala (CeA), which is relatively rich in NT and neurotensin-1 receptors (NTS1), participates in the regulation of memory and learning mechanisms. The aim of this study was to examine the possible effect of NT and NTS1 antagonist (ANT) on passive avoidance learning after their microinjection into the CeA of male wistar rats. NT significantly increased the latency time. Effect of NT was blocked by ANT pretreatment. ANT in itself had no effect. Our results show that in the rat CeA NT facilitates passive avoidance learning via NTS1.
Copyright © 2011. Published by Elsevier B.V.

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Year:  2011        PMID： 21946307     DOI： 10.1016/j.bbr.2011.08.041

Source DB:  PubMed          Journal:  Behav Brain Res        ISSN： 0166-4328            Impact factor:   3.332


  6 in total

1.  Amygdala nuclei critical for emotional learning exhibit unique gene expression patterns.

Authors:  Alexander C Partin; Matthew P Hosek; Jonathan A Luong; Srihari K Lella; Sachein A R Sharma; Jonathan E Ploski
Journal:  Neurobiol Learn Mem       Date:  2013-07-02       Impact factor: 2.877

2.  The effect of the steroid sulfatase inhibitor (p-O-sulfamoyl)-tetradecanoyl tyramine (DU-14) on learning and memory in rats with selective lesion of septal-hippocampal cholinergic tract.

Authors:  P A Babalola; N F Fitz; R B Gibbs; P T Flaherty; P-K Li; D A Johnson
Journal:  Neurobiol Learn Mem       Date:  2012-09-26       Impact factor: 2.877

3.  Effect of low doses of methamphetamine on rat limbic-related neurotensin systems.

Authors:  Mario E Alburges; Amanda J Hoonakker; Nathaniel M Cordova; Christina M Robson; Lisa M McFadden; Amber L Martin; Glen R Hanson
Journal:  Synapse       Date:  2015-06-11       Impact factor: 2.562

Review 4.  Neurotensin in reward processes.

Authors:  María Luisa Torruella-Suárez; Zoe A McElligott
Journal:  Neuropharmacology       Date:  2020-02-11       Impact factor: 5.250

5.  Maternal separation enhances conditioned fear and decreases the mRNA levels of the neurotensin receptor 1 gene with hypermethylation of this gene in the rat amygdala.

Authors:  Hiroyuki Toda; Shuken Boku; Shin Nakagawa; Takeshi Inoue; Akiko Kato; Naoki Takamura; Ning Song; Masashi Nibuya; Tsukasa Koyama; Ichiro Kusumi
Journal:  PLoS One       Date:  2014-05-15       Impact factor: 3.240

6.  Ionic and signaling mechanisms involved in neurotensin-mediated excitation of central amygdala neurons.

Authors:  Saobo Lei; Binqi Hu
Journal:  Neuropharmacology       Date:  2021-07-14       Impact factor: 5.273
  6 in total

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