| Literature DB >> 21945933 |
Yongsheng Huang1, Yang Yang, Rui Gao, Xianmei Yang, Xiaohua Yan, Chenji Wang, Sirui Jiang, Long Yu.
Abstract
TGF-β (transforming growth factor-β), a pleiotropic cytokine that regulates diverse cellular processes, has been suggested to play critical roles in cell proliferation, migration, and carcinogenesis. Here we found a novel E3 ubiquitin ligase RLIM which can directly bind to Smurf2, enhancing TGF-β responsiveness in osteosarcoma U2OS cells. We constructed a U2OS cell line stably over-expressing RLIM and demonstrated that RLIM promoted TGF-β-driven migration of U2OS cells as tested by wound healing assay. Our results indicated that RLIM is an important positive regulator in TGF-β signaling pathway and cell migration.Entities:
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Year: 2011 PMID： 21945933 DOI： 10.1016/j.bbrc.2011.09.053
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575