BACKGROUND: Chronic ischemic mitral regurgitation (MR) is associated with poor outcome. However, the effect of chronic ischemic MR on left ventricular (LV) remodeling after posterolateral myocardial infarction (MI) remains controversial. We tested the hypothesis that moderate MR accelerates LV remodeling after posterolateral MI. METHODS: Posterolateral MI was created in 10 sheep. Cardiac magnetic resonance imaging was performed 2 weeks before and 2, 8, and 16 weeks after MI. Left ventricular and right ventricular volumes were measured, and regurgitant volume was calculated as the difference between LV and right ventricle stroke volumes. RESULTS: Multivariate mixed effects regression showed that LV volumes at end diastole and end systole and LV sphericity were strongly correlated with both regurgitant volume (p < 0.0001, p = 0.0086, and p = 0.0007, respectively) and percent infarct area (p = 0.0156, p = 0.0307, and p < 0.0001, respectively). Conversely, whereas LV hypertrophy (LV wall volume) increased from 2 weeks to 16 weeks after MI, there was no effect of either regurgitant volume or percent infarct. CONCLUSIONS: Moderate MR accelerates LV remodeling after posterolateral MI. Further studies are needed to determine whether mitral valve repair is able to slow or reverse MI remodeling after posterolateral MI. Copyright Â
BACKGROUND:Chronic ischemic mitral regurgitation (MR) is associated with poor outcome. However, the effect of chronic ischemic MR on left ventricular (LV) remodeling after posterolateral myocardial infarction (MI) remains controversial. We tested the hypothesis that moderate MR accelerates LV remodeling after posterolateral MI. METHODS: Posterolateral MI was created in 10 sheep. Cardiac magnetic resonance imaging was performed 2 weeks before and 2, 8, and 16 weeks after MI. Left ventricular and right ventricular volumes were measured, and regurgitant volume was calculated as the difference between LV and right ventricle stroke volumes. RESULTS: Multivariate mixed effects regression showed that LV volumes at end diastole and end systole and LV sphericity were strongly correlated with both regurgitant volume (p < 0.0001, p = 0.0086, and p = 0.0007, respectively) and percent infarct area (p = 0.0156, p = 0.0307, and p < 0.0001, respectively). Conversely, whereas LV hypertrophy (LV wall volume) increased from 2 weeks to 16 weeks after MI, there was no effect of either regurgitant volume or percent infarct. CONCLUSIONS: Moderate MR accelerates LV remodeling after posterolateral MI. Further studies are needed to determine whether mitral valve repair is able to slow or reverse MI remodeling after posterolateral MI. Copyright Â
Authors: Peng Zhang; Julius M Guccione; Susan I Nicholas; Joseph C Walker; Philip C Crawford; Amin Shamal; Gabriel Acevedo-Bolton; Michael A Guttman; Cengizhan Ozturk; Elliot R McVeigh; David A Saloner; Arthur W Wallace; Mark B Ratcliffe Journal: J Thorac Cardiovasc Surg Date: 2007-10 Impact factor: 5.209
Authors: Ronen Beeri; Chaim Yosefy; J Luis Guerrero; Francesca Nesta; Suzan Abedat; Miguel Chaput; Federica del Monte; Mark D Handschumacher; Robert Stroud; Suzanne Sullivan; Thea Pugatsch; Dan Gilon; Gus J Vlahakes; Francis G Spinale; Roger J Hajjar; Robert A Levine Journal: J Am Coll Cardiol Date: 2008-01-29 Impact factor: 24.094
Authors: Yong-Hwan Kim; Lawrence S C Czer; Harmik J Soukiasian; Michele De Robertis; Kathy E Magliato; Carlos Blanche; Sharo S Raissi; James Mirocha; Robert J Siegel; Robert M Kass; Alfredo Trento Journal: Ann Thorac Surg Date: 2005-06 Impact factor: 4.330
Authors: W G Hundley; H F Li; J E Willard; C Landau; R A Lange; B M Meshack; L D Hillis; R M Peshock Journal: Circulation Date: 1995-09-01 Impact factor: 29.690
Authors: S T Kelley; R Malekan; J H Gorman; B M Jackson; R C Gorman; Y Suzuki; T Plappert; D K Bogen; M G Sutton; L H Edmunds Journal: Circulation Date: 1999 Jan 5-12 Impact factor: 29.690
Authors: Ronen Beeri; Chaim Yosefy; J Luis Guerrero; Suzan Abedat; Mark D Handschumacher; Robert E Stroud; Suzanne Sullivan; Miguel Chaput; Dan Gilon; Gus J Vlahakes; Francis G Spinale; Roger J Hajjar; Robert A Levine Journal: Circulation Date: 2007-09-11 Impact factor: 29.690
Authors: Robert A Levine; Albert A Hagége; Daniel P Judge; Muralidhar Padala; Jacob P Dal-Bianco; Elena Aikawa; Jonathan Beaudoin; Joyce Bischoff; Nabila Bouatia-Naji; Patrick Bruneval; Jonathan T Butcher; Alain Carpentier; Miguel Chaput; Adrian H Chester; Catherine Clusel; Francesca N Delling; Harry C Dietz; Christian Dina; Ronen Durst; Leticia Fernandez-Friera; Mark D Handschumacher; Morten O Jensen; Xavier P Jeunemaitre; Hervé Le Marec; Thierry Le Tourneau; Roger R Markwald; Jean Mérot; Emmanuel Messas; David P Milan; Tui Neri; Russell A Norris; David Peal; Maelle Perrocheau; Vincent Probst; Michael Pucéat; Nadia Rosenthal; Jorge Solis; Jean-Jacques Schott; Ehud Schwammenthal; Susan A Slaugenhaupt; Jae-Kwan Song; Magdi H Yacoub Journal: Nat Rev Cardiol Date: 2015-10-20 Impact factor: 32.419
Authors: Liang Ge; Yife Wu; Mehrdad Soleimani; Michael Khazalpour; Kiyoaki Takaba; Mehrzad Tartibi; Zhihong Zhang; Gabriel Acevedo-Bolton; David A Saloner; Arthur W Wallace; Rakesh Mishra; Eugene A Grossi; Julius M Guccione; Mark B Ratcliffe Journal: Ann Thorac Surg Date: 2016-02-06 Impact factor: 4.330
Authors: Joe Luis Pantoja; Liang Ge; Zhihong Zhang; William G Morrel; Julius M Guccione; Eugene A Grossi; Mark B Ratcliffe Journal: Ann Thorac Surg Date: 2014-08-15 Impact factor: 4.330
Authors: Joe Luis Pantoja; Ashley E Morgan; Eugene A Grossi; Morten O Jensen; Jonathan W Weinsaft; Robert A Levine; Liang Ge; Mark B Ratcliffe Journal: Ann Thorac Surg Date: 2016-10-05 Impact factor: 4.330
Authors: Rafael Shimkunas; Zhihong Zhang; Jonathan F Wenk; Mehrdad Soleimani; Michael Khazalpour; Gabriel Acevedo-Bolton; Guanying Wang; David Saloner; Rakesh Mishra; Arthur W Wallace; Liang Ge; Anthony J Baker; Julius M Guccione; Mark B Ratcliffe Journal: Ann Thorac Surg Date: 2013-03-21 Impact factor: 4.330
Authors: Kimberly Spaulding; Kiyoaki Takaba; Alexander Collins; Farshid Faraji; Guanying Wang; Esteban Aguayo; Liang Ge; David Saloner; Arthur W Wallace; Anthony J Baker; David H Lovett; Mark B Ratcliffe Journal: PLoS One Date: 2018-02-12 Impact factor: 3.240
Authors: Yue Zhang; Vicky Y Wang; Ashley E Morgan; Jiwon Kim; Mark D Handschumacher; Chaya S Moskowitz; Robert A Levine; Liang Ge; Julius M Guccione; Jonathan W Weinsaft; Mark B Ratcliffe Journal: PLoS One Date: 2019-10-10 Impact factor: 3.240