| Literature DB >> 21945070 |
Sini Nurmenniemi1, Marja-Kaisa Koivula, Pia Nyberg, Taina Tervahartiala, Timo Sorsa, Petri S Mattila, Tuula Salo, Juha Risteli.
Abstract
Cancer invasion induces extracellular matrix remodeling and collagen degradation. The aim of this study was to assess whether serum levels of type I and III collagen degradation products were associated with patient survival in head and neck squamous cell carcinoma (HNSCC). A novel enzyme immunoassay was developed for measuring type III collagen N-terminal telopeptide (IIINTP) in human serum samples. In addition, type I collagen C-terminal telopeptide (ICTP), matrix metalloprotease-8 (MMP-8) and tissue inhibitor of metalloproteases-1 (TIMP-1) were assessed in 205 blood samples from HNSCC patients. High levels of serum ICTP and IIINTP and plasma TIMP-1 were associated with poor survival. The concentration of ICTP was associated with levels of IIINTP and TIMP-1. The plasma concentration of MMP-8 was associated with tumor stage, but not with survival or levels of ICTP, IIINTP or TIMP-1 suggesting that other collagenases/proteases are responsible for the cleavage of type I and type III collagens. The rate of type I and type III collagen degradation is associated with patient survival and can be used as a prognostic marker in HNSCC.Entities:
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Year: 2011 PMID： 21945070 DOI： 10.1016/j.oraloncology.2011.09.002
Source DB: PubMed Journal: Oral Oncol ISSN： 1368-8375 Impact factor: 5.337