PURPOSE: Existing data on the relation between gallstones and kidney stones are provocative but limited. Therefore, we determined whether symptomatic radiographically confirmed gallstones (and/or cholecystectomy) and symptomatic kidney stone disease are independently associated. MATERIALS AND METHODS: We conducted cross-sectional and prospective analyses in the Nurses' Health Studies I and II (older and younger women, respectively) and the Health Professionals Follow-Up Study (men) that included more than 240,000 participants followed for 14 to 24 years. Regression models adjusted for age, body size, thiazide use, diet and other factors. RESULTS: At baseline the multivariate odds ratio of kidney stone history in individuals with gallstone history compared to those without was 1.65 (95% CI 1.46-1.86) in older women, 1.85 (95% CI 1.65-2.07) in younger women and 1.61 (95% CI 1.41-1.85) in men. Prospectively, the multivariate relative risk of incident kidney stones in participants with gallstone history compared to those without was 1.26 (95% CI 1.09-1.44) in older women, 1.32 (95% CI 1.14-1.52) in younger women and 1.28 (95% CI 1.03-1.57) in men. The multivariate relative risk of incident gallstones in participants with kidney stone history compared to those without was 1.17 (95% CI 1.06-1.29) in older women, 1.31 (95% CI 1.19-1.45) in younger women and 1.51 (95% CI 1.35-1.68) in men. Prospective lag analyses instituting a delay of 4 years between the diagnoses of gallstones and kidney stones yielded similar results. CONCLUSIONS: Gallstones and kidney stones are independently associated. Additional studies are needed to identify shared mechanisms underlying both diseases.
PURPOSE: Existing data on the relation between gallstones and kidney stones are provocative but limited. Therefore, we determined whether symptomatic radiographically confirmed gallstones (and/or cholecystectomy) and symptomatic kidney stone disease are independently associated. MATERIALS AND METHODS: We conducted cross-sectional and prospective analyses in the Nurses' Health Studies I and II (older and younger women, respectively) and the Health Professionals Follow-Up Study (men) that included more than 240,000 participants followed for 14 to 24 years. Regression models adjusted for age, body size, thiazide use, diet and other factors. RESULTS: At baseline the multivariate odds ratio of kidney stone history in individuals with gallstone history compared to those without was 1.65 (95% CI 1.46-1.86) in older women, 1.85 (95% CI 1.65-2.07) in younger women and 1.61 (95% CI 1.41-1.85) in men. Prospectively, the multivariate relative risk of incident kidney stones in participants with gallstone history compared to those without was 1.26 (95% CI 1.09-1.44) in older women, 1.32 (95% CI 1.14-1.52) in younger women and 1.28 (95% CI 1.03-1.57) in men. The multivariate relative risk of incident gallstones in participants with kidney stone history compared to those without was 1.17 (95% CI 1.06-1.29) in older women, 1.31 (95% CI 1.19-1.45) in younger women and 1.51 (95% CI 1.35-1.68) in men. Prospective lag analyses instituting a delay of 4 years between the diagnoses of gallstones and kidney stones yielded similar results. CONCLUSIONS:Gallstones and kidney stones are independently associated. Additional studies are needed to identify shared mechanisms underlying both diseases.
Authors: J E Manson; E B Rimm; M J Stampfer; G A Colditz; W C Willett; A S Krolewski; B Rosner; C H Hennekens; F E Speizer Journal: Lancet Date: 1991-09-28 Impact factor: 79.321
Authors: Michael F Leitzmann; Meir J Stampfer; Walter C Willett; Donna Spiegelman; Graham A Colditz; Edward L Giovannucci Journal: Gastroenterology Date: 2002-12 Impact factor: 22.682
Authors: W C Willett; L Sampson; M J Stampfer; B Rosner; C Bain; J Witschi; C H Hennekens; F E Speizer Journal: Am J Epidemiol Date: 1985-07 Impact factor: 4.897
Authors: G A Colditz; P Martin; M J Stampfer; W C Willett; L Sampson; B Rosner; C H Hennekens; F E Speizer Journal: Am J Epidemiol Date: 1986-05 Impact factor: 4.897
Authors: Kari Hemminki; Otto Hemminki; Anni I M Koskinen; Asta Försti; Kristina Sundquist; Jan Sundquist; Xinjun Li Journal: BMC Nephrol Date: 2018-07-03 Impact factor: 2.388
Authors: M Reza Jabalameli; Fiona M Fitzpatrick; Roberto Colombo; Sarah A Howles; Gary Leggatt; Valerie Walker; Akira Wiberg; Edmund R S Kunji; Sarah Ennis Journal: Mol Genet Genomic Med Date: 2021-08-04 Impact factor: 2.183