Literature DB >> 21943593

Wnt signaling as a potential therapeutic target for frontotemporal dementia.

Zeljka Korade1, Károly Mirnics.   

Abstract

Progranulin mutations result in frontotemporal dementia, but the underlying pathophysiology has remained largely unexplained. New data by Geschwind and colleagues in this issue of Neuron uncovered that the Wnt/FZD2 signaling pathway is an early and critical contributor to disease pathology.
Copyright © 2011 Elsevier Inc. All rights reserved.

Entities:  

Year:  2011        PMID： 21943593      PMCID： PMC3183459          DOI： 10.1016/j.neuron.2011.09.002

Source DB:  PubMed          Journal:  Neuron        ISSN： 0896-6273            Impact factor:   17.173


  15 in total

1.  Functional genomic analyses identify pathways dysregulated by progranulin deficiency, implicating Wnt signaling.

Authors:  Ezra Y Rosen; Eric M Wexler; Revital Versano; Giovanni Coppola; Fuying Gao; Kellen D Winden; Michael C Oldham; Lauren Herl Martens; Ping Zhou; Robert V Farese; Daniel H Geschwind
Journal:  Neuron       Date:  2011-09-21       Impact factor: 17.173

2.  A general framework for weighted gene co-expression network analysis.

Authors:  Bin Zhang; Steve Horvath
Journal:  Stat Appl Genet Mol Biol       Date:  2005-08-12

Review 3.  The Wnt/beta-catenin signaling pathway as a target in drug discovery.

Authors:  Fumi Takahashi-Yanaga; Toshiyuki Sasaguri
Journal:  J Pharmacol Sci       Date:  2007-08       Impact factor: 3.337

Review 4.  A neurotrophic rationale for the therapy of neurodegenerative disorders.

Authors:  H Uri Saragovi; Edith Hamel; Adriana Di Polo
Journal:  Curr Alzheimer Res       Date:  2009-10       Impact factor: 3.498

5.  Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice.

Authors:  Fangfang Yin; Rebecca Banerjee; Bobby Thomas; Ping Zhou; Liping Qian; Ting Jia; Xiaojing Ma; Yao Ma; Costantino Iadecola; M Flint Beal; Carl Nathan; Aihao Ding
Journal:  J Exp Med       Date:  2009-12-21       Impact factor: 14.307

6.  Proteomic and functional analyses reveal a mitochondrial dysfunction in P301L tau transgenic mice.

Authors:  Della C David; Susanne Hauptmann; Isabel Scherping; Katrin Schuessel; Uta Keil; Patrizia Rizzu; Rivka Ravid; Stefan Dröse; Ulrich Brandt; Walter E Müller; Anne Eckert; Jürgen Götz
Journal:  J Biol Chem       Date:  2005-04-14       Impact factor: 5.157

7.  Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity.

Authors:  Yong-Jie Zhang; Ya-Fei Xu; Casey Cook; Tania F Gendron; Paul Roettges; Christopher D Link; Wen-Lang Lin; Jimei Tong; Monica Castanedes-Casey; Peter Ash; Jennifer Gass; Vijayaraghavan Rangachari; Emanuele Buratti; Francisco Baralle; Todd E Golde; Dennis W Dickson; Leonard Petrucelli
Journal:  Proc Natl Acad Sci U S A       Date:  2009-04-21       Impact factor: 11.205

Review 8.  The molecular basis of frontotemporal dementia.

Authors:  Manuela Neumann; Markus Tolnay; Ian R A Mackenzie
Journal:  Expert Rev Mol Med       Date:  2009-07-29       Impact factor: 5.600

Review 9.  The Wnt pathway, cell-cycle activation and beta-amyloid: novel therapeutic strategies in Alzheimer's disease?

Authors:  Andrea Caricasole; Agata Copani; Alessandra Caruso; Filippo Caraci; Luisa Iacovelli; Maria Angela Sortino; Georg C Terstappen; Ferdinando Nicoletti
Journal:  Trends Pharmacol Sci       Date:  2003-05       Impact factor: 14.819

Review 10.  Mutations in progranulin (GRN) within the spectrum of clinical and pathological phenotypes of frontotemporal dementia.

Authors:  John C van Swieten; Peter Heutink
Journal:  Lancet Neurol       Date:  2008-09-02       Impact factor: 44.182
View more
  7 in total

1.  Progranulin protects against osteoarthritis through interacting with TNF-α and β-Catenin signalling.

Authors:  Yun-Peng Zhao; Qing-Yun Tian; Ben Liu; Jian-Lu Wei; Brendon Richbourgh; Chuan-Ju Liu
Journal:  Ann Rheum Dis       Date:  2014-08-28       Impact factor: 19.103

Review 2.  Insights into the role of progranulin in immunity, infection, and inflammation.

Authors:  Jinlong Jian; Jessica Konopka; Chuanju Liu
Journal:  J Leukoc Biol       Date:  2012-10-22       Impact factor: 4.962

3.  Platelet-derived growth factor-BB restores HIV Tat -mediated impairment of neurogenesis: role of GSK-3β/β-catenin.

Authors:  Jie Chao; Lu Yang; Honghong Yao; Shilpa Buch
Journal:  J Neuroimmune Pharmacol       Date:  2013-11-19       Impact factor: 4.147

4.  Restoration of progranulin expression rescues cortical neuron generation in an induced pluripotent stem cell model of frontotemporal dementia.

Authors:  Susanna Raitano; Laura Ordovàs; Louis De Muynck; Wenting Guo; Ira Espuny-Camacho; Martine Geraerts; Satish Khurana; Kim Vanuytsel; Balazs I Tóth; Thomas Voets; Rik Vandenberghe; Toni Cathomen; Ludo Van Den Bosch; Pierre Vanderhaeghen; Philip Van Damme; Catherine M Verfaillie
Journal:  Stem Cell Reports       Date:  2014-12-31       Impact factor: 7.765

5.  Downregulation of exosomal miR-204-5p and miR-632 as a biomarker for FTD: a GENFI study.

Authors:  Raphael Schneider; Paul McKeever; TaeHyung Kim; Caroline Graff; John Cornelis van Swieten; Anna Karydas; Adam Boxer; Howie Rosen; Bruce L Miller; Robert Laforce; Daniela Galimberti; Mario Masellis; Barbara Borroni; Zhaolei Zhang; Lorne Zinman; Jonathan Daniel Rohrer; Maria Carmela Tartaglia; Janice Robertson
Journal:  J Neurol Neurosurg Psychiatry       Date:  2018-02-06       Impact factor: 10.154

6.  Genetically Engineered iPSC-Derived FTDP-17 MAPT Neurons Display Mutation-Specific Neurodegenerative and Neurodevelopmental Phenotypes.

Authors:  An Verheyen; Annick Diels; Joke Reumers; Kirsten Van Hoorde; Ilse Van den Wyngaert; Constantin van Outryve d'Ydewalle; An De Bondt; Jacobine Kuijlaars; Louis De Muynck; Ronald De Hoogt; Alexis Bretteville; Steffen Jaensch; Arjan Buist; Alfredo Cabrera-Socorro; Selina Wray; Andreas Ebneth; Peter Roevens; Ines Royaux; Pieter J Peeters
Journal:  Stem Cell Reports       Date:  2018-07-26       Impact factor: 7.765

7.  Platelet-derived growth factor CC-mediated neuroprotection against HIV Tat involves TRPC-mediated inactivation of GSK 3beta.

Authors:  Fuwang Peng; Honghong Yao; Halis Kaan Akturk; Shilpa Buch
Journal:  PLoS One       Date:  2012-10-15       Impact factor: 3.240
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.