Literature DB >> 21942345

Moving out: from sterol transport to drug resistance - the ABCG subfamily of efflux pumps.

Karobi Moitra1, Latoya Silverton, Katy Limpert, Kate Im, Michael Dean.   

Abstract

The ATP binding cassette (ABC) proteins are typically ATP-driven transmembrane pumps that have been evolutionarily conserved from bacteria to humans. In humans these transporters are subdivided into seven subfamilies, ranging from A to G. The ABCG subfamily of transporters is the primary focus of this review. This subfamily of proteins has been conserved throughout evolution and plays a central role in several cellular processes, such as sterol homeostasis and multidrug resistance. Functional polymorphisms/mutations in some of these G-subfamily transporters have clinical consequences in humans.

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Year:  2011        PMID： 21942345      PMCID： PMC7380564          DOI： 10.1515/DMDI.2011.015

Source DB:  PubMed          Journal:  Drug Metabol Drug Interact        ISSN： 0792-5077


  38 in total

1.  Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters.

Authors:  K E Berge; H Tian; G A Graf; L Yu; N V Grishin; J Schultz; P Kwiterovich; B Shan; R Barnes; H H Hobbs
Journal:  Science       Date:  2000-12-01       Impact factor: 47.728

2.  ABCG4: a novel human white family ABC-transporter expressed in the brain and eye.

Authors:  Susan Oldfield; Christopher Lowry; Jon Ruddick; Stafford Lightman
Journal:  Biochim Biophys Acta       Date:  2002-08-19

3.  ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a regulator of macrophage cholesterol and phospholipid transport.

Authors:  J Klucken; C Büchler; E Orsó; W E Kaminski; M Porsch-Ozcürümez; G Liebisch; M Kapinsky; W Diederich; W Drobnik; M Dean; R Allikmets; G Schmitz
Journal:  Proc Natl Acad Sci U S A       Date:  2000-01-18       Impact factor: 11.205

4.  ABCG1 redistributes cell cholesterol to domains removable by high density lipoprotein but not by lipid-depleted apolipoproteins.

Authors:  Ashley M Vaughan; John F Oram
Journal:  J Biol Chem       Date:  2005-06-30       Impact factor: 5.157

5.  Multidrug efflux pumps and cancer stem cells: insights into multidrug resistance and therapeutic development.

Authors:  K Moitra; H Lou; M Dean
Journal:  Clin Pharmacol Ther       Date:  2011-03-02       Impact factor: 6.875

6.  Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption.

Authors:  M H Lee; K Lu; S Hazard; H Yu; S Shulenin; H Hidaka; H Kojima; R Allikmets; N Sakuma; R Pegoraro; A K Srivastava; G Salen; M Dean; S B Patel
Journal:  Nat Genet       Date:  2001-01       Impact factor: 38.330

7.  A new multidrug resistance protein at the blood-brain barrier.

Authors:  Tanja Eisenblätter; Hans-Joachim Galla
Journal:  Biochem Biophys Res Commun       Date:  2002-05-17       Impact factor: 3.575

8.  Divergent evolution and evolution by the birth-and-death process in the immunoglobulin VH gene family.

Authors:  T Ota; M Nei
Journal:  Mol Biol Evol       Date:  1994-05       Impact factor: 16.240

9.  Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout.

Authors:  Owen M Woodward; Anna Köttgen; Josef Coresh; Eric Boerwinkle; William B Guggino; Michael Köttgen
Journal:  Proc Natl Acad Sci U S A       Date:  2009-06-08       Impact factor: 11.205

10.  ATP-binding cassette transporters G1 and G4 mediate cellular cholesterol efflux to high-density lipoproteins.

Authors:  Nan Wang; Debin Lan; Wengen Chen; Fumihiko Matsuura; Alan R Tall
Journal:  Proc Natl Acad Sci U S A       Date:  2004-06-21       Impact factor: 11.205
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  7 in total

Review 1.  The formation and function of plant cuticles.

Authors:  Trevor H Yeats; Jocelyn K C Rose
Journal:  Plant Physiol       Date:  2013-07-26       Impact factor: 8.340

Review 2.  The human ATP-binding cassette (ABC) transporter superfamily.

Authors:  Michael Dean; Karobi Moitra; Rando Allikmets
Journal:  Hum Mutat       Date:  2022-06-22       Impact factor: 4.700

Review 3.  ABC transporter superfamily. An updated overview, relevance in cancer multidrug resistance and perspectives with personalized medicine.

Authors:  Pérez-De Marcos Juan-Carlos; Pérez-Pineda Perla-Lidia; Méndez-Morales Stephanie-Talia; Arellano-Mendoza Mónica-Griselda; Torres-Espíndola Luz-María
Journal:  Mol Biol Rep       Date:  2021-02-22       Impact factor: 2.316

4.  Tissue-specific transcript profiling for ABC transporters in the sequestering larvae of the phytophagous leaf beetle Chrysomela populi.

Authors:  Anja S Strauss; Ding Wang; Magdalena Stock; René R Gretscher; Marco Groth; Wilhelm Boland; Antje Burse
Journal:  PLoS One       Date:  2014-06-02       Impact factor: 3.240

5.  LABCG2, a new ABC transporter implicated in phosphatidylserine exposure, is involved in the infectivity and pathogenicity of Leishmania.

Authors:  Jenny Campos-Salinas; David León-Guerrero; Elena González-Rey; Mario Delgado; Santiago Castanys; José M Pérez-Victoria; Francisco Gamarro
Journal:  PLoS Negl Trop Dis       Date:  2013-04-25

6.  Efflux pumps of Gram-negative bacteria: what they do, how they do it, with what and how to deal with them.

Authors:  Leonard Amaral; Ana Martins; Gabriella Spengler; Joseph Molnar
Journal:  Front Pharmacol       Date:  2014-01-03       Impact factor: 5.810

7.  The Structure and Mechanism of Drug Transporters.

Authors:  Arthur G Roberts
Journal:  Methods Mol Biol       Date:  2021
  7 in total

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