BACKGROUND AND PURPOSE: Previous ultrasound-based studies have shown an association between carotid artery atherosclerosis and dementia. Our aim was to investigate this association using postmortem examination. METHODS: Postmortem morphometric measurements of carotid stenosis and intima-media thickness were performed in individuals with dementia (n=112) and control subjects (n=577). Multivariate logistic regression models were applied. RESULTS: High-grade left internal carotid stenosis (≥70%) was associated with increased odds for dementia (OR, 2.30; 95% CI, 1.14-4.74; P=0.02). Intima-media thickness was not associated with dementia. CONCLUSIONS: The likelihood of dementia is increased with high-grade left internal carotid artery atherosclerosis after adjusting for demographic and cardiovascular risk factors.
BACKGROUND AND PURPOSE: Previous ultrasound-based studies have shown an association between carotid artery atherosclerosis and dementia. Our aim was to investigate this association using postmortem examination. METHODS: Postmortem morphometric measurements of carotid stenosis and intima-media thickness were performed in individuals with dementia (n=112) and control subjects (n=577). Multivariate logistic regression models were applied. RESULTS: High-grade left internal carotid stenosis (≥70%) was associated with increased odds for dementia (OR, 2.30; 95% CI, 1.14-4.74; P=0.02). Intima-media thickness was not associated with dementia. CONCLUSIONS: The likelihood of dementia is increased with high-grade left internal carotid artery atherosclerosis after adjusting for demographic and cardiovascular risk factors.
Authors: Claudia K Suemoto; Lea T Grinberg; Renata E P Leite; Renata E L Ferretti-Rebustini; Wilson Jacob-Filho; Kristine Yaffe; Ricardo Nitrini; Carlos A Pasqualucci Journal: Atherosclerosis Date: 2017-12-09 Impact factor: 5.162
Authors: Carrington R Wendell; Shari R Waldstein; Luigi Ferrucci; Richard J O'Brien; James B Strait; Alan B Zonderman Journal: Stroke Date: 2012-10-25 Impact factor: 7.914
Authors: Qinghai Liu; Shuhan He; Leonid Groysman; David Shaked; Jonathan Russin; Thomas C Scotton; Steven Cen; William J Mack Journal: PLoS One Date: 2013-12-30 Impact factor: 3.240
Authors: Christian Spinelli; Maria Fara De Caro; Gabriella Schirosi; Domenico Mezzapesa; Lorenzo De Benedittis; Concetta Chiapparino; Gabriella Serio; Francesco Federico; Pietro Nazzaro Journal: Int J Med Sci Date: 2014-05-29 Impact factor: 3.738