OBJECTIVE: There is a wide spectrum of established and emerging genetic mutations associated with intraadrenal and extraadrenal paragangliomas. In this review, we present the typical radiologic patterns of disease associated with six well-characterized genetic mutations and discuss other inherited and nonfamilial syndromes currently under characterization. CONCLUSION: Contrary to previous understanding, recent genotype advances suggest that the majority of paragangliomas may be genetically predisposed.
OBJECTIVE: There is a wide spectrum of established and emerging genetic mutations associated with intraadrenal and extraadrenal paragangliomas. In this review, we present the typical radiologic patterns of disease associated with six well-characterized genetic mutations and discuss other inherited and nonfamilial syndromes currently under characterization. CONCLUSION: Contrary to previous understanding, recent genotype advances suggest that the majority of paragangliomas may be genetically predisposed.