Zuhai Ren1, Yong Xu, Shaihong Zhu. 1. Department of General Surgery, Central South University, Changsha, China. zuhai123@yahoo.com.cn
Abstract
BACKGROUND/AIMS: The aim of this study was to investigate the effect of terlipressin on hepatic hemodynamics in small-for-size livers at early phase after major hepatectomy. METHODOLOGY: Thirty-six rats were divided into treatment group (Group Th) and control group (Group Ch) for hemodynamic study. Hepatic hemodynamic parameters were detected before hepatectomy (baseline values), 30min, 1h, and 2h after reperfusion. Twenty rats were divided into the treatment group (Group Ts) and control group (Group Cs) for survival study. The survival rate and hemodynamic parameters were studied. RESULTS: The 10-day survival rate of the Ts group was significantly higher than that of the Cs group (p<0.05). The portal pressure of Group Th1/2 was significantly lower than that of Group Ch1/2 (p<0.05). Portal pressure of Group Th1 was significantly lower than that of Group Ch1 (p<0.05). The portal blood flow of Group Th1/2 was significantly lower than that of Group Ch1/2, and so was that between Group Th1 and Ch1, (both p<0.05). The portal blood flow of Group Ch1/2 was significantly higher compared to its baseline value (p<0.05). CONCLUSIONS: The survival rate of rats with small-for-size liver can be significantly improved by terlipressin. Terlipressin ameliorates portal hyperperfusion in small-for-size liver by effectively reducing portal pressure and portal blood flow at early phase after hepatectomy.
BACKGROUND/AIMS: The aim of this study was to investigate the effect of terlipressin on hepatic hemodynamics in small-for-size livers at early phase after major hepatectomy. METHODOLOGY: Thirty-six rats were divided into treatment group (Group Th) and control group (Group Ch) for hemodynamic study. Hepatic hemodynamic parameters were detected before hepatectomy (baseline values), 30min, 1h, and 2h after reperfusion. Twenty rats were divided into the treatment group (Group Ts) and control group (Group Cs) for survival study. The survival rate and hemodynamic parameters were studied. RESULTS: The 10-day survival rate of the Ts group was significantly higher than that of the Cs group (p<0.05). The portal pressure of Group Th1/2 was significantly lower than that of Group Ch1/2 (p<0.05). Portal pressure of Group Th1 was significantly lower than that of Group Ch1 (p<0.05). The portal blood flow of Group Th1/2 was significantly lower than that of Group Ch1/2, and so was that between Group Th1 and Ch1, (both p<0.05). The portal blood flow of Group Ch1/2 was significantly higher compared to its baseline value (p<0.05). CONCLUSIONS: The survival rate of rats with small-for-size liver can be significantly improved by terlipressin. Terlipressin ameliorates portal hyperperfusion in small-for-size liver by effectively reducing portal pressure and portal blood flow at early phase after hepatectomy.
Authors: Jorge Carrapita; Ana Margarida Abrantes; Sofia Campelos; Ana Cristina Gonçalves; Dulce Cardoso; Ana Bela Sarmento-Ribeiro; Clara Rocha; Jorge Nunes Santos; Maria Filomena Botelho; José Guilherme Tralhão; Olivier Farges; Jorge Maciel Barbosa Journal: Sci Rep Date: 2016-10-11 Impact factor: 4.379