| Literature DB >> 21940072 |
Esther del Olmo1, Bianca Barboza, Louise D Chiaradia, Alicia Moreno, Juana Carrero-Lérida, Dolores González-Pacanowska, Victoria Muñoz, José L López-Pérez, Alberto Giménez, Agustín Benito, Antonio R Martínez, Luis M Ruiz-Pérez, Arturo San Feliciano.
Abstract
The synthesis of several series of imidazo[2,1-a]isoindol-5-ol derivatives and the results of their evaluation against Plasmodium falciparum are presented and discussed. The effects of electron-withdrawing or-donating substituents on different parts of the molecule, as well as those produced by the incorporation of an additional fused ring, were analyzed. Several compounds showed significant antimalarial activity in vitro with IC(50) values as low as 60 nM and a certain efficacy in vivo by reducing parasitemia in Plasmodium berghei mouse models.Entities:
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Year: 2011 PMID： 21940072 DOI： 10.1016/j.ejmech.2011.08.043
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514