Literature DB >> 2193962

[The action of chemical agents at ultralow doses on biological objects].

E B Burlakova, A A Kondradov, I V Khudiakov.   

Abstract

The published data on the effect of low and ultralow (up to 10(-17] doses of chemical agents on different biological systems have been reviewed. A concept of action of ultralow doses has been proposed on the basis of a notion of complex hierarchical structure of regulation in biological systems where response to strong and weak actions is carried out by different mechanisms and pathways. The times of transport of molecules of biologically active compounds to targets have been calculated on the basis of the principle of the first boundary approach by Brown's particle. Probabilistic models of mechanisms leading to complex dose dependency have been analyzed.

Mesh:

Year:  1990        PMID: 2193962

Source DB:  PubMed          Journal:  Izv Akad Nauk SSSR Biol        ISSN: 0002-3329


  2 in total

1.  The role of solvent polarity in the mechanism of action of biologically active compounds at ultralow concentrations.

Authors:  V V Belov; E L Mal'tseva; N P Pal'mina; E B Burlakova
Journal:  Dokl Biochem Biophys       Date:  2004 Nov-Dec       Impact factor: 0.788

2.  In vitro bioassay as a predictor of in vivo response.

Authors:  Ross Barnard; Konstantin G Gurevich
Journal:  Theor Biol Med Model       Date:  2005-02-07       Impact factor: 2.432

  2 in total

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